Medication Use Among Pregnant Women With SARS-CoV-2 Infection and Risk of Hospitalization-A Study in Two Brazilian Hospitals.

Autor: Rohweder R; Graduate Program in Genetics and Molecular Biology Department of Genetics Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Pereira NG; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Micheletti BH; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Mosello J; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Campos JRM; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Pereira MG; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Santos CN; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Simões NL; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Matielo RLB; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil., Bernardes LS; Department of Obstetrics and Neonatology Hospital e Maternidade SEPACO, São Paulo, Brazil.; Center for Klinisk Forskning and Afdeling for Kvindesygdomme, Graviditet og Fødsel North Denmark Regional Hospital, Hjørring, Denmark., Oppermann MLR; Gynecology and Obstetrics Service Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Wender MCO; Gynecology and Obstetrics Service Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Lupattelli A; PharmacoEpidemiology and Drug Safety Research Group Department of Pharmacy University of Oslo, Oslo, Norway., Nordeng H; PharmacoEpidemiology and Drug Safety Research Group Department of Pharmacy University of Oslo, Oslo, Norway., Schuler-Faccini L; Graduate Program in Genetics and Molecular Biology Department of Genetics Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Journal of pregnancy [J Pregnancy] 2024 Jun 06; Vol. 2024, pp. 8915166. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).
DOI: 10.1155/2024/8915166
Abstrakt: There is limited evidence about the use of medications among pregnant women with COVID-19, as well as risk factors for hospitalization due to COVID-19 in pregnancy. We aimed to describe the use of medications among SARS-CoV-2-positive pregnant women at the time around infection and identify predictors for hospitalization due to COVID-19 in two hospitals in Brazil. This is a hospital record-based study among pregnant women with positive SARS-CoV-2 tests between March 2020 and August 2022 from two Brazilian hospitals. Characteristics of sociodemographic, obstetrical, and COVID-19 symptoms were extracted retrospectively. The prevalence use of medications was based on self-reported use, and this was administered at the hospital. Logistic regression was used to estimate predictors of hospitalization due to COVID-19. There were 278 pregnant women included in the study, of which 41 (14.7%) required hospitalization due to COVID-19. The remaining 237 (85.3%) had mild symptoms or were asymptomatic. Most of the women had the infection in the third trimester ( n = 149; 53.6%). The most prevalent medications used across all trimesters were analgesics (2.4% to 20.0%), antibacterials (15.0% to 23.1%), and corticosteroids (7.2% to 10.4%). Pre- or gestational hypertensive disorder (odds ratio (OR) 4.94, 95% confidence interval (CI) 1.65, 14.87) and having at least one dose of vaccine against SARS-CoV-2 (OR 0.13, 95% CI 0.04, 0.39) were associated with hospitalization due to COVID-19. Analgesics, antibacterials, and corticosteroids were the most frequently used medications among pregnant women with COVID-19. Women with hypertensive disorders have almost a five-fold increased risk of hospitalization due to COVID-19. Vaccination was the strongest protective factor for severe COVID-19. The COVID-19 vaccination among pregnant women should be promoted, and pregnant women diagnosed with COVID-19 who have hypertensive disorders should be closely monitored.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2024 Ricardo Rohweder et al.)
Databáze: MEDLINE
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