In chronic spontaneous urticaria, increased Galectin-9 expression on basophils and eosinophils is linked to high disease activity, endotype-specific markers, and response to omalizumab treatment.

Autor: Ji J; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou, China., Tang M; Department of Dermatology, The First Affiliated Hospital of Hainan Medical University, Haikou, China., Zhao Y; Suzhou Kowloon hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China., Zhang C; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou, China., Shen Y; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China., Zhou B; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China., Liu C; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China., Maurer M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Jiao Q; Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jazyk: angličtina
Zdroj: Allergy [Allergy] 2024 Sep; Vol. 79 (9), pp. 2435-2447. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1111/all.16239
Abstrakt: Background: Galectin-9 (Gal-9) has been implicated in allergic and autoimmune diseases, but its role and relevance in chronic spontaneous urticaria (CSU) are unclear.
Objectives: To characterize the role and relevance of Gal-9 in the pathogenesis of CSU.
Methods: We assessed 60 CSU patients for their expression of Gal-9 on circulating eosinophils and basophils as well as T cell expression of the Gal-9 receptor TIM-3, compared them with 26 healthy controls (HCs), and explored possible links with disease features including disease activity (urticaria activity score, UAS), total IgE, basophil activation test (BAT), and response to omalizumab treatment. We also investigated potential drivers of Gal-9 expression by eosinophils and basophils.
Results: Our CSU patients had markedly increased rates of circulating Gal-9 + eosinophils and basophils and high numbers of lesional Gal-9 + cells. High rates of blood Gal-9 + eosinophils/basophils were linked to high disease activity, IgE levels, and BAT negativity. Serum levels of TNF-α were positively correlated with circulating Gal-9 + eosinophils/basophils, and TNF-α markedly upregulated Gal-9 on eosinophils. CSU patients who responded to omalizumab treatment had more Gal-9 + eosinophils/basophils than non-responders, and omalizumab reduced blood levels of Gal-9 + eosinophils/basophils in responders. Gal-9 + eosinophils/basophils were negatively correlated with TIM-3 + T H 17 cells.
Conclusion: Our findings demonstrate a previously unrecognized involvement of the Gal-9/TIM-3 pathway in the pathogenesis CSU and call for studies that explore its relevance.
(© 2024 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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