| Autor: |
Wu Z; Heilongjiang University of Chinese Medicine, Harbin 150040, China., Jiao MY; Jinhua Maternal and Child Health Hospital, Jinhua 321000, Zhejiang Province., Zou W; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040. kuangzou1965@163.com. |
| Jazyk: |
English; Chinese |
| Zdroj: |
Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2024 Jul 25; Vol. 49 (7), pp. 767-776. |
| DOI: |
10.13702/j.1000-0607.20230232 |
| Abstrakt: |
Stroke brings the pathological changes of brain tissues such as hematoma formation or ischemia and hypoxia, which leads to neuronal death and axon degeneration. Axon regeneration after its injury is mainly dependent on the surrounding microenvironment and the related proteins, including glial scar, myelin associated inhibitory factors, axon guidance molecules, and neurotrophic factors. All of them affect axon growth by regulating the morphology and orientation of growth cones, the synaptic stability, and the proliferation and differentiation of neural stem cells. This article summarizes the mechanism of acupuncture in regulating axon regeneration after stroke. Acupuncture inhibits glial scar formation, alleviates the inhibitory effects of its physical and chemical barriers on axon growth, reverses the inhibitory effects of myelin-related inhibitory factors on axon growth, and adjusts the level of axon guidance molecules to promote the proliferation and differentiation of neural stem cells and the regeneration of injured axons, and up-regulates neurotrophic factors. Eventually, post-stroke nerve injury can be ameliorated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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