Psilocybin desynchronizes the human brain.

Autor: Siegel JS; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. jssiegel@wustl.edu., Subramanian S; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA., Perry D; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Kay BP; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Gordon EM; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA., Laumann TO; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Reneau TR; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA., Metcalf NV; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Chacko RV; Department of Emergency Medicine, Advocate Christ Health Care, Oak Lawn, IL, USA., Gratton C; Department of Psychology, Florida State University, Tallahassee, FL, USA., Horan C; Miami VA Medical Center, Miami, FL, USA., Krimmel SR; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Shimony JS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA., Schweiger JA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Wong DF; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA., Bender DA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Scheidter KM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Whiting FI; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Padawer-Curry JA; Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA., Shinohara RT; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chen Y; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Moser J; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA., Yacoub E; Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA., Nelson SM; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Vizioli L; Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA., Fair DA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.; Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Lenze EJ; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Carhart-Harris R; Department of Neurology, University of California, San Francisco, CA, USA.; Centre for Psychedelic Research, Imperial College London, London, UK., Raison CL; Usona Institute, Fitchburg, WI, USA.; Department of Psychiatry, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA., Raichle ME; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA.; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, USA., Snyder AZ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA., Nicol GE; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Dosenbach NUF; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA.; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO, USA.; Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Aug; Vol. 632 (8023), pp. 131-138. Date of Electronic Publication: 2024 Jul 17.
DOI: 10.1038/s41586-024-07624-5
Abstrakt: A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials 1-4 . In animal models, psilocybin induces neuroplasticity in cortex and hippocampus 5-8 . It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6-12 months later. Psilocybin massively disrupted functional connectivity (FC) in cortex and subcortex, acutely causing more than threefold greater change than methylphenidate. These FC changes were driven by brain desynchronization across spatial scales (areal, global), which dissolved network distinctions by reducing correlations within and anticorrelations between networks. Psilocybin-driven FC changes were strongest in the default mode network, which is connected to the anterior hippocampus and is thought to create our sense of space, time and self. Individual differences in FC changes were strongly linked to the subjective psychedelic experience. Performing a perceptual task reduced psilocybin-driven FC changes. Psilocybin caused persistent decrease in FC between the anterior hippocampus and default mode network, lasting for weeks. Persistent reduction of hippocampal-default mode network connectivity may represent a neuroanatomical and mechanistic correlate of the proplasticity and therapeutic effects of psychedelics.
(© 2024. The Author(s).)
Databáze: MEDLINE
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