Time trends of the association of body mass index with mortality in 3.5 million young Swedish adults.

Autor: Mboya IB; Department of Translational Medicine, Lund University, Malmö, Sweden. Electronic address: innocent.mboya@med.lu.se., Fritz J; Department of Translational Medicine, Lund University, Malmö, Sweden; Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria., da Silva M; Department of Translational Medicine, Lund University, Malmö, Sweden., Sun M; Department of Translational Medicine, Lund University, Malmö, Sweden., Wahlström J; Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sandin S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Yin W; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Söderberg S; Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, CA, USA., Lagerros YT; Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Center for Obesity, Academic Specialist Center, Stockholm Health Services, Stockholm, Sweden., Nwaru BI; Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Kankaanranta H; Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Chabok A; Center for Clinical Research, Region Västmanland, Uppsala University, Uppsala, Sweden., Leppert J; Center for Clinical Research, Region Västmanland, Uppsala University, Uppsala, Sweden., Backman H; Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden., Hedman L; Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden., Isaksson K; Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Surgery, Kristianstad Hospital, Kristianstad, Sweden., Michaëlsson K; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Häggström C; Department of Diagnostics and Intervention, and Northern Registry Centre, Umeå University, Umeå, Sweden., Stocks T; Department of Translational Medicine, Lund University, Malmö, Sweden.
Jazyk: angličtina
Zdroj: Annals of epidemiology [Ann Epidemiol] 2024 Sep; Vol. 97, pp. 23-32. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1016/j.annepidem.2024.07.043
Abstrakt: Purpose: We investigated time trends of the obesity-mortality association, accounting for age, sex, and cause-specific deaths.
Methods: We analysed pooled nationwide data in Sweden for 3,472,310 individuals aged 17-39 years at baseline in 1963-2016. Cox regression and flexible parametric survival models investigated BMI-mortality associations in sub-groups of sex and baseline calendar years (men: <1975, 1975-1985, ≥1985 and women: <1985, 1985-1994, ≥1995).
Results: Comparing men with obesity vs. normal weight, all-cause and "other-cause" mortality associations decreased over periods; HR (95% CI) 1.92 (1.83-2.01) and 1.70 (1.58-1.82) for all-cause and 1.72 (1.58-1.87) and 1.40 (1.28-1.53) for "other-cause" mortality in <1975 and ≥1985, but increased for CVD mortality; HR 2.71 (2.51-2.94) and 3.91 (3.37-4.53). Higher age at death before 1975 coincided with more obesity-related deaths at higher ages. Furthermore, the all-cause mortality association for different ages in men showed no clear differences between periods (p-interaction=0.09), suggesting no calendar effect after accounting for attained age. Similar, but less pronounced, results were observed in women. Associations with cancer mortality showed no clear trends in men or in women.
Conclusions: Accounting for differences in age and death causes between calendar periods when investigating BMI-mortality time trends may avoid misinterpreting the risks associated with obesity over time.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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