The Troubling Rise of Scurvy: A Review and National Analysis of Incidence, Associated Risk Factors, and Clinical Manifestations.
| Autor: | Reikersdorfer KN; From the Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA (Ms. Reikersdorfer, Dr. Young, Dr. Batty, Dr. Steele, Dr. Yuen, Dr. Liu, and Dr. Hogue) Department of Orthopaedics, UT Health San Antonio, San Antonio, TX (Mr. Singh, and Dr. Momtaz); and the Department of Pediatrics, Boston Children's Hospital, Boston, MA (Dr. Weissert)., Singh A, Young JD, Batty MB, Steele AE, Yuen LC, Momtaz DA, Weissert JN, Liu DS, Hogue GD |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews [J Am Acad Orthop Surg Glob Res Rev] 2024 Jul 15; Vol. 8 (7). Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024). |
| DOI: | e24.00162 |
| Abstrakt: | Introduction: In the era of modern medicine, scurvy has been thought of as a rare disease of ancient times because of improved emphasis on diet and nutrition; however, isolated case reports are plentiful. This investigation presents a comprehensive review of scurvy, including an analysis on its rising incidence, with specific focus on its orthopaedic manifestations and commonly associated diagnoses. Methods: This comprehensive review includes a retrospective analysis of 19,413,465 pediatric patients in the National Inpatient Sample database from 2016 through 2020. Patients with scurvy were identified by the ICD-10 code, and an estimated incidence of scurvy in the inpatient pediatric population was calculated. Concurrent diagnoses, musculoskeletal reports, and demographic variables were collected from patient records. Comparisons were made using analysis of variance or chi-square with Kendall tau, where appropriate. Results: The incidence of scurvy increased over the study period, from 8.2 per 100,000 in 2016 to 26.7 per 100,000 in 2020. Patients with scurvy were more likely to be younger (P < 0.001), male (P = 0.010), in the lowest income quartile (P = 0.013), and obese (P < 0.001). A majority (64.2%) had a concomitant diagnosis of autism spectrum disorder. Common presenting musculoskeletal reports included difficulty walking, knee pain, and lower limb deformity. Burden of disease of scurvy was markedly greater than that of the average inpatient population, with these patients experiencing greater total charges and longer hospital stays. Conclusion: Clinicians should be aware of the increasing incidence of scurvy in modern medicine. In cases of vague musculoskeletal reports without clear etiology, a diagnosis of scurvy should be considered, particularly if risk factors are present. Trial Registration Number: NA. (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Orthopaedic Surgeons.) |
| Databáze: | MEDLINE |
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