Purpura fulminans secondary to varicella-zoster virus infection.

Autor:	Işık AD; Marmara University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey., Sakarya AH; Marmara University Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul, Turkey., Erdemli PC; Marmara University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey., Ergenc Z; Marmara University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey., Yılmaz S; Marmara University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey., Tuncay SA; Marmara University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey., Parlak B; Marmara University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey., Doğru Ö; Marmara University Faculty of Medicine, Division of Pediatric Hematology and Oncology, Department of Pediatrics, Istanbul, Turkey., Koç A; Marmara University Faculty of Medicine, Division of Pediatric Hematology and Oncology, Department of Pediatrics, Istanbul, Turkey., Girgin Fİ; Marmara University Faculty of Medicine, Division of Pediatric Intensive Care Unit, Department of Pediatrics, Istanbul, Turkey., Kepenekli E; Bahçeşehir University Faculty of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Wounds : a compendium of clinical research and practice [Wounds] 2024 Jun; Vol. 36 (6), pp. 201-205.
DOI:	10.25270/wnds/23155
Abstrakt:	Background: Purpura fulminans (PF) is a rare, life-threatening condition involving consumptive coagulopathy and intravascular thrombosis, causing purpura and necrosis in the skin and soft tissue. Case Report: A 4-year-old Tajik girl with PF secondary to varicella-zoster virus (VZV) infection presented with purplish red, diffuse, painful lesions localized to the entire right leg. Her vaccination status was unknown, and she did not have concurrent chronic illness. Ten days before admission, the girl was admitted to another hospital in Tajikistan with a diagnosis of chickenpox and PF. She was then transferred to the hospital of the authors of the current report due to the enlargement of lesions to the gluteal region, a change in the color of lesions from red to black, and the detection of arterial thrombosis via Doppler ultrasonography. Multiple surgical debridements were performed to manage tissue necrosis, and the patient's right leg was amputated at the 18th week of admission. The patient was discharged after 26 weeks of hospitalization. Conclusion: Although VZV infections mostly cause mild and self-limiting eruptive disease, they can progress, with life-threatening complications, including PF. To prevent VZV infection and resulting complications, immunization with live attenuated vaccines and maintaining population immunity above a certain threshold are the most important strategies to prevent the circulation of the virus.
Databáze:	MEDLINE
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