Neuropsychological functioning after COVID-19: minor differences between individuals with and without persistent complaints after SARS-CoV-2 infection.

Autor:	Verveen A; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam, The Netherlands., Verfaillie SCJ; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Radiology & Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam, The Netherlands.; GGz inGeest Specialized Mental Health Care, Amsterdam, The Netherlands., Visser D; Radiology & Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam, The Netherlands., Koch DW; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Verwijk E; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam, The Netherlands.; Psychology department, Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands., Geurtsen GJ; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Roor J; Department of Medical Psychology, VieCuri Medical Center, Venlo, The Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Appelman B; Center for Experimental and Molecular Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Boellaard R; Radiology & Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam, The Netherlands., van Heugten CM; Department of Neuropsychology and Psychopharmacology, and Limburg Brain Injury Center, Faculty of Psychology, Neuroscience Maastricht University, Maastricht, The Netherlands., Horn J; Amsterdam Neuroscience, Amsterdam, The Netherlands.; Intensive Care, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Hulst HE; Department of Medical, Health and Neuropsychology, Leiden University, Leiden, The Netherlands., de Jong MD; Infectious Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Medical Microbiology & Infection Prevention, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Kuut TA; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam, The Netherlands., van der Maaden T; Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., van Os YMG; Occupational Health Office, Department of Human Resources, University Medical Center Utrecht, Utrecht, The Netherlands., Prins M; Infectious Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands., Visser-Meily JMA; Department of Rehabilitation, Physical Therapy Science and Sports, University Medical Centre Utrecht, Utrecht, The Netherlands., van Vugt M; Internal Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., van den Wijngaard CC; Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Nieuwkerk PT; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam, The Netherlands., van Berckel B; Radiology & Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Amsterdam, The Netherlands., Tolboom N; Department of Radiology and Nuclear Medicine, Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Knoop H; Department of Medical Psychology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The Clinical neuropsychologist [Clin Neuropsychol] 2024 Jul 17, pp. 1-16. Date of Electronic Publication: 2024 Jul 17.
DOI:	10.1080/13854046.2024.2379508
Abstrakt:	Objective: It is unclear how self-reported severe fatigue and difficulty concentrating after SARS-CoV-2 infection relate to objective neuropsychological functioning. The study aimed to compare neuropsychological functioning between individuals with and without these persistent subjective complaints. Method : Individuals with and without persistent severe fatigue (Checklist Individual Strength (CIS) fatigue ≥ 35) and difficulty concentrating (CIS concentration ≥ 18) at least 3 months after SARS-CoV-2 infection were included. Neuropsychological assessment was performed on overall cognitive functioning, attention, processing speed, executive functioning, memory, visuo-construction, and language (18 tests). T-scores -1.5 SD below population normative data ( T  ≤ 35) were classified as "impaired". Results: 230 participants were included in the study, of whom 22 were excluded from the analysis due to invalid performance. Of the participants included in the analysis, 111 reported persistent complaints of severe fatigue and difficulty concentrating and 97 did not. Median age was 54 years, 59% ( n  = 126) were female, and participants were assessed a median of 23 months after first infection (IQR: 16-28). With bivariate logistic regression, individuals with persistent complaints had an increased likelihood of slower information processing speed performance on the Stroop word reading (OR = 2.45, 95%CI = 1.02-5.84) compared to those without persistent complaints. Demographic or clinical covariates (e.g. hospitalization) did not influence this association. With linear regression techniques, persistent complaints were associated with lower t-scores on the D2 CP, TMT B, and TMT B|A. There were no differences in performance on the other neuropsychological tests. Conclusions: Individuals with subjective severe fatigue and difficulty concentrating after COVID-19 do not typically demonstrate cognitive impairment on extensive neuropsychological testing.
Databáze:	MEDLINE
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