The association of umbilical cord blood oxidative stress with maternal iron deficiency anemia: A tertiary center experience.

Autor: Farisoğullari N; Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Tanaçan A; Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Sakcak B; Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Denizli R; Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Özdemir EÜ; Department of Gynecology and Obstetrics, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Elmas B; Department of Gynecology and Obstetrics, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Canpolat FE; Department of Neonatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Neşelioğlu S; Department of Biochemistry, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Erel Ö; Department of Biochemistry, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey., Şahin D; Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2024 Dec; Vol. 167 (3), pp. 1201-1206. Date of Electronic Publication: 2024 Jul 17.
DOI: 10.1002/ijgo.15808
Abstrakt: Objective: To compare the levels of oxidative stress markers in the umbilical cord blood between pregnant women diagnosed with iron deficiency anemia (IDA) and low-risk controls.
Methods: The sample consisted of 131 patients, including 55 pregnant women with IDA and 76 controls with similar demographic characteristics. Participants were selected from patients delivered at ≥37 weeks. We compared the two groups in terms of the native thiol, total thiol, disulfide, and ischemia-modified albumin (IMA) levels measured in pregnant women's umbilical cord venous blood.
Results: The native thiol and total thiol values were statistically significantly lower in the anemia group, and the disulfide and IMA values were statistically significantly higher in the IDA group (P < 0.001). Perinatal outcomes were similar between the groups.
Conclusion: In the present study, pregnant women with IDA had lower native and total thiol values and higher disulfide and IMA values in umbilical cord blood. Iron deficiency anemia in pregnancy may be a potential cause of increased oxidative stress.
(© 2024 International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
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