Three Molecular Developmental Pathways of Remnant Pancreatic Cancer after Resection: A Nationwide Project Study of Japan Pancreas Society.

Autor:	Suzuki S; Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Ami, 300-0395, Japan., Omori Y; Department of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, 065-0033, Japan., Ono Y; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, 065-0033, Japan.; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, Asahikawa, 078-8510, Japan., Hirose K; Department of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Itoh T; Department of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Karasaki H; Department of Surgery, Engaru Kosei Hospital, Monbetsu, 099-0404, Japan., Shimoda M; Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Ami, 300-0395, Japan., Nagakawa Y; Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, 160-8402, Japan., Higuchi R; Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, 162-8666, Japan., Endo I; Department of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan., Rikiyama T; Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan., Unno M; Department of Surgery, Tohoku University Graduate School of Medicine. Sendai, 980-8575, Japan., Fujii T; Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, 930-0194, Japan., Sunagawa Y; Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, 466-8560, Japan., Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, 565-0871, Japan., Sasanuma H; Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Shimotsuke, 329-0498, Japan., Akahori T; Department of Surgery, Nara Medical University, Kashihara, 634-8522, Japan., Okano K; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Miki, 761-0793, Japan., Tani M; Department of Surgery, Shiga University of Medical Science, Ohtsu, 520-2192, Japan., Hirano S; Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, 060-8648, Japan., Shimizu Y; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, 464-8681, Japan., Kitago M; Department of Surgery, Keio University School of Medicine, Tokyo, 160-8582, Japan., Mizuno S; Hepatobiliary Pancreatic and Transplant Surgery, Mie University Hospital, Tsu, 514-8507, Japan., Yamamoto T; Department of Surgery, Kansai Medical University, Hirakata, 573-1191, Japan., Furukawa M; Department of Hepato-Biliary-Pancreatology, National Hospital Organization Kyushu Cancer Center, Fukuoka, 811-1395, Japan., Ohtsuka M; Department of General Surgery, Chiba University, Chiba, 260-8677, Japan., Sugimoto M; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan., Matsushita A; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, 113-8603, Japan., Hakamada K; Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8563, Japan., Igarashi H; Igarashi Medical Clinic, Shimonoseki, 751-0827, Japan., Kuroki T; Department of Surgery, NHO Nagasaki Medical Center, Omura, 856-8562, Japan., Tanno S; Department of Gastroenterology, IMS Sapporo Digestive Disease Center General Hospital, Sapporo, 063-0842, Japan., Tsuji Y; Department of General Medicine, Sapporo Medical University, Sapporo, 060-8543, Japan., Masamune A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan., Mizumoto K; International University of Health and Welfare, Tokyo, 107-8402, Japan., Hirooka Y; Department of Gastroenterology and Hepatology, Fujita Health University School of Medicine, Toyoake, 470-1192, Japan., Yamaue H; Second Department of Surgery, Wakayama Medical University, Wakayama, 641-8510, Japan., Okazaki K; Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, 573-1191, Japan., Satoi S; Department of Surgery, Kansai Medical University, Hirakata, 573-1191, Japan., Takeyama Y; Department of Surgery, Kindai University School of Medicine, Osakasayama, 589-8511, Japan., Mizukami Y; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, 065-0033, Japan.; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, Asahikawa, 078-8510, Japan., Furukawa T; Department of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Jazyk:	angličtina
Zdroj:	Annals of surgery [Ann Surg] 2024 Jul 17. Date of Electronic Publication: 2024 Jul 17.
DOI:	10.1097/SLA.0000000000006444
Abstrakt:	Objective: This study aimed to clarify the molecular mechanism of remnant pancreatic cancer (PC) development after primary PC resection. Summary Background Data: Molecular mechanisms of the development of remnant PCs following primary PC resection are largely unknown. Methods: Forty-three patients undergoing remnant PC resection after primary PC resection between 2001 and 2017 at 26 institutes were retrospectively analyzed. Clinicopathological features and molecular alterations detected by targeted amplicon sequencing of 36 PC-associated genes were evaluated. Results: These patients showed significantly lower body mass indices and higher hemoglobin A1c values at remnant PC resection than at primary PC resection. A comparison of the molecular features between primary and remnant PCs indicated that remnant PCs were likely to develop via three different molecular pathways: successional, showing identical and accumulated alterations (n=14); phylogenic, showing identical and distinct alterations (n=26); and distinct, showing independent distinctive alterations (n=3). The similarity of gene alterations was associated with time to the remnant PC development (r=－0.384, P=0.0173). Phylogenic pathways were significantly associated with the intraductal spread of carcinoma (P=0.007). Patient survival did not differ significantly depending on these molecular pathways. Conclusion: Molecular profiling uncovered three pathways for the development of remnant PCs, namely, successional, phylogenic, and distinct pathways. The vast majority of remnant PCs are likely to be molecularly associated with primary PCs either in the successional or phylogenic way. This information could impact the design of a strategy for monitoring and treating remnant PCs. Competing Interests: Disclosures: All authors disclose no personal and financial conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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