Neuroanatomy of cerebellar mutism syndrome: the role of lesion location.

Autor:	Skye J; Department of Neurology, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Department of Psychiatry, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA., Bruss J; Department of Neurology, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Toescu S; Department of Neurosurgery, Great Ormond Street Hospital, London WC1N 3JH, UK.; Developmental Imaging and Biophysics Section, UCL-GOS Institute of Child Health, London WC1N 1EH, UK., Aquilina K; Department of Neurosurgery, Great Ormond Street Hospital, London WC1N 3JH, UK., Grafft A; Department of Pediatrics, Division of Developmental and Behavioral Pediatrics, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Bardi Lola G; Department of Pediatrics, Division of Hematology/Oncology, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Boes AD; Department of Neurology, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Department of Psychiatry, University of Iowa Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2024 Jun 05; Vol. 6 (4), pp. fcae197. Date of Electronic Publication: 2024 Jun 05 (Print Publication: 2024).
DOI:	10.1093/braincomms/fcae197
Abstrakt:	Approximately 25% of paediatric patients who undergo cerebellar tumour resection develop cerebellar mutism syndrome. Our group recently showed that damage to the cerebellar deep nuclei and superior cerebellar peduncles, which we refer to as the cerebellar outflow pathway, is associated with an increased risk of cerebellar mutism syndrome. Here, we tested whether these findings replicate in an independent cohort. We evaluated the relationship between lesion location and the development of cerebellar mutism syndrome in an observational study of 56 paediatric patients ranging from five months to 14 years of age who underwent cerebellar tumour resection. We hypothesized that individuals who developed cerebellar mutism syndrome after surgery, relative to those who did not, would have lesions that preferentially intersect with: (i) the cerebellar outflow pathway and (ii) a previously generated 'lesion-symptom map' of cerebellar mutism syndrome. Analyses were conducted in accordance with pre-registered hypotheses and analytic methods (https://osf.io/r8yjv/). We found supporting evidence for both hypotheses. Compared to patients who did not develop cerebellar mutism syndrome, patients with cerebellar mutism syndrome ( n = 10) had lesions with greater overlap with the cerebellar outflow pathway (Cohen's d = 0.73, P = 0.05), and the cerebellar mutism syndrome lesion-symptom map (Cohen's d = 1.1, P = 0.004). These results strengthen the association of lesion location with the risk of developing cerebellar mutism syndrome and demonstrate generalizability across cohorts. These findings may help to inform the optimal surgical approach to paediatric cerebellar tumours. Competing Interests: The authors report no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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