Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.

Autor: Helwig NJ; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA., Schwager LE; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA., Berry AC; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA., Zucker AC; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA., Venenga JS; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA., Sterbenz SC; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA., Jenkins NDM; University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.; University of Iowa, Abboud Cardiovascular Research Center, Iowa City, IA, USA.
Jazyk: angličtina
Zdroj: Journal of the International Society of Sports Nutrition [J Int Soc Sports Nutr] 2024 Dec; Vol. 21 (1), pp. 2379424. Date of Electronic Publication: 2024 Jul 16.
DOI: 10.1080/15502783.2024.2379424
Abstrakt: Purpose: We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an Ilex guayusa tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.
Methods: Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE 600 ) or 1200 mg (GLE 1200 ) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing. Blood pressure (BP), heart rate, and QT interval length were determined before and after supplementation.
Results: GLE 600 significantly improved total mood disturbance (mean ± SE difference = -6.9 ± 2.6 au, p  = 0.034), fatigue-inertia (-2.84 ± 0.89 au, p  = 0.008), perceived energy (+13.00 ± 4.49 au; p  = 0.02), motor speed (+4.52 ± 1.42 au, p  = 0.008), and psychomotor speed (+7.20 ± 2.16 au, p  = 0.005) relative to PLA. GLE 1200 also improved psychomotor speed (+5.08 ± 2.16 ms, p  = 0.045) and uniquely increased motor-cognitive performance as reflected by a decrease in reaction time (-0.106 ± 0.04 ms, p  = 0.026) during a neurocognitive hop test. The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only ( p  < 0.001). Both GLE 600 and GLE 1200 similarly increased systolic and diastolic BP by 4-5 mmHg ( p  ≤ 0.022). Neither GLE 600 nor GLE 1200 acutely influenced QTc length ( p  = 0.31).
Conclusions: The goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.
Databáze: MEDLINE
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