Impact of post-hepatectomy biliary leaks on long-term survival in different liver tumors: A single institute experience.

Autor:	Ballal DS; Division of Colon and Rectal Surgery, Advocate Lutheran General Hospital, Park Ridge, IL, USA., Patkar S; Department of Surgical Oncology, GI and HPB Services, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Kunte A; Department of Surgical Oncology, GI and HPB Services, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Sundaram S; Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Shetty N; Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Gala K; Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Kulkarni S; Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India., Goel M; Department of Surgical Oncology, GI and HPB Services, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Jazyk:	angličtina
Zdroj:	Annals of hepato-biliary-pancreatic surgery [Ann Hepatobiliary Pancreat Surg] 2024 Jul 17. Date of Electronic Publication: 2024 Jul 17.
DOI:	10.14701/ahbps.24-078
Abstrakt:	Backgrounds/aims: A postoperative biliary leak is one of the most morbid complications occurring after a liver resection, the long-term impact of which remains unknown. Methods: Retrospective analysis of consecutive liver resections performed from 1 January 2011 to 31 December 2021. Primary endpoint of disease-free survival (DFS) was compared between patients with and without a bile leak, stratifying for tumor type. Survival curves were plotted using Kaplan-Meier estimates, and differences between them were analyzed using the log-rank test. Results: In toto, 862 patients were analyzed, and included 306 (35.5%) hepatocellular carcinomas, 212 (24.6%) metastatic colorectal cancers, and 111 (12.9%) cholangiocarcinomas (69 intrahepatic cholangiocarcinomas, 42 hilar cholangiocarcinomas). Occurrence of a bile leak was associated with significantly poorer DFS only in patients with cholangiocarcinoma (median DFS 9.9 months vs. 24.9 months, p = 0.013), and further analysis was restricted to this cohort. A Cox regression performed for factors associated with DFS detriment in patients with cholangiocarcinoma showed that apart from node positivity (hazard ratio [HR]: 2.482, p = 0.033) and margin positivity (HR: 2.65, p = 0.021), development of a bile leak was independently associated with worsening DFS on both univariate and multiple regression analyses (HR: 1.896, p = 0.033). Conclusions: Post-hepatectomy biliary leaks are associated with significantly poorer DFS only in patients with cholangiocarcinoma, but not in patients with hepatocellular carcinoma or metastatic colorectal cancer. Methods to mitigate this survival detriment need to be explored.
Databáze:	MEDLINE
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