Physical Performance and Telomere Length in Older Adults.
Autor: | Martínez-Ezquerro JD; Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, Mexico., Ortiz-Ramírez M; Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., García-de la Torre P; Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., González-Covarrubias V; Laboratorio de Farmacogenómica, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Sánchez-García S; Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address: sergio.sanchezga@imss.gob.mx. |
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Jazyk: | angličtina |
Zdroj: | Archives of medical research [Arch Med Res] 2024 Sep; Vol. 55 (6), pp. 103046. Date of Electronic Publication: 2024 Jul 15. |
DOI: | 10.1016/j.arcmed.2024.103046 |
Abstrakt: | Background: The aging population prompts studying risk factors and markers to predict healthy aging. Telomere length is a promising candidate for assessing various age-related traits. Aim of the Study: To investigate the association between physical performance and telomere length. Methods: We enrolled 323 older Mexican adults from the "Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults" affiliated with the Instituto Mexicano del Seguro Social and assessed their physical performance using the Short Physical Performance Battery, dividing participants into low (≤7) and high (>7) groups. Absolute telomere length was determined by qPCR, and individuals were classified into short (≤4.22 kb) and long (>4.22 kb) groups. We calculated the mean and adjusted mean, considering sex and age, among others, with 95% CI. We estimated the effect size between physical performance and telomere length using Cohen's d for unequal group sizes and calculated the odds ratio for physical performance based on telomere length. Results: Participants with low physical performance had significantly shorter telomeres (mean Conclusion: Decreased physical function is associated with shorter telomere length. Absolute telomere length presents a promising biomarker for distinguishing between healthy and unhealthy aging, warranting further investigation. Competing Interests: Conflicts of Interest The authors declare no competing interests. (Copyright © 2024. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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