Opsoclonus-Ataxia Syndrome in a Patient With Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.

Autor:	Farina A; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France., Villagrán-García M; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France., Benaiteau M; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France., Lamblin F; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France., Fourier A; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France., Honnorat J; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France., Joubert B; From the French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (A. Farina, M.V.-G., M.B., J.H., B.J.), Hospices Civils de Lyon, Hôpital Neurologique, Bron; MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1; Department of Neurology (F.L.), University Hospital of La Réunion, Saint-Pierre; and Lyon Neuroscience Research Center (CRNL) (A. Fourier), Université de Lyon, CNRS, INSERM, France.
Jazyk:	angličtina
Zdroj:	Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2024 Sep; Vol. 11 (5), pp. e200287. Date of Electronic Publication: 2024 Jul 16.
DOI:	10.1212/NXI.0000000000200287
Abstrakt:	Objectives: To describe a case of post-immune checkpoint inhibitor (ICI) opsoclonus-myoclonus-ataxia syndrome (OMAS), with complete clinical remission after treatment. Methods: A 52-year-old man was admitted because of subacute-onset vertigo, dysarthria, vomiting, and weight loss. He was under atezolizumab (anti-PD-L1) monotherapy (23 cycles) for metastatic small-cell lung cancer, with excellent response. Results: On examination (1 month after symptom onset), the patient had opsoclonus, dysarthria, severe truncal and gait ataxia, and mild appendicular ataxia without myoclonus (SARA score 26/40). Brain MRI showed mild cerebellar atrophy, and CSF analysis disclosed pleocytosis and oligoclonal bands. Anti-SOX1 antibodies were detected in serum and CSF. Atezolizumab was stopped, and corticosteroids and monthly IV immunoglobulins were administered. Chemotherapy (carboplatin and etoposide) was also started because of cancer progression. Three months later, examination showed regression of the opsoclonus, truncal ataxia, and dysarthria and persistence of very mild gait ataxia (SARA score 3.5/40), which completely regressed at last examination (20 months after onset). Discussion: The clinical pattern and reversibility bring the present case close to a few patients with paraneoplastic OMAS described before the ICI era. More research is needed to clarify the pathogenesis and outcomes of OMAS in the context of ICI.
Databáze:	MEDLINE
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