Age- and Sex-Specific Myocardial Blood Flow Values in Patients Without Coronary Atherosclerosis on Rb-82 PET Myocardial Perfusion Imaging.

Autor:	Sperry BW; Saint Luke's Mid America Heart Institute, Kansas City, MO (B.W.S., M.P.M., R.C.T., A.I.M.G., T.M.B.).; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., Metzinger MP; Saint Luke's Mid America Heart Institute, Kansas City, MO (B.W.S., M.P.M., R.C.T., A.I.M.G., T.M.B.).; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., Ibrahim AO; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., Thompson RC; Saint Luke's Mid America Heart Institute, Kansas City, MO (B.W.S., M.P.M., R.C.T., A.I.M.G., T.M.B.).; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., Cho YJ; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., Jones PG; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., McGhie AI; Saint Luke's Mid America Heart Institute, Kansas City, MO (B.W.S., M.P.M., R.C.T., A.I.M.G., T.M.B.).; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.)., Bateman TM; Saint Luke's Mid America Heart Institute, Kansas City, MO (B.W.S., M.P.M., R.C.T., A.I.M.G., T.M.B.).; University of Missouri-Kansas City (B.W.S., M.P.M., A.O.I., R.C.T., Y.J.C., P.G.J., A.I.M.G., T.M.B.).
Jazyk:	angličtina
Zdroj:	Circulation. Cardiovascular imaging [Circ Cardiovasc Imaging] 2024 Jul; Vol. 17 (7), pp. e016577. Date of Electronic Publication: 2024 Jul 16.
DOI:	10.1161/CIRCIMAGING.124.016577
Abstrakt:	Background: Quantitative myocardial blood flow (MBF) on positron-emission tomography myocardial perfusion imaging is a measure of the overall health of the coronary circulation. The ability to adequately augment blood flow, measured by myocardial blood flow reserve (MBFR), is associated with lower major adverse cardiovascular events and all-cause mortality. The age-specific ranges of MBFR in patients without demonstrable coronary artery disease have not been well established. We aimed to determine the effect of age and sex on MBF in a cohort of patients without demonstrable coronary artery disease. Methods: Patients who underwent positron-emission tomography myocardial perfusion imaging studies from 2012 to 2022 on positron-emission tomography/computed tomography cameras were included if the summed stress score was 0, the coronary calcium score was 0, and the left ventricular ejection fraction was ≥50%. Those with known coronary artery disease, prior history of coronary intervention, diabetes, heart/kidney/liver transplant, cirrhosis, or chronic kidney disease stage IV+ were excluded. MBF was calculated using a net retention model (ImagenQ, Cardiovascular Imaging Technologies, Kansas City), and quantile regression models were developed to predict MBF. Results: Among 2789 patients (age 59.9±13.0 years, 76.4% females), median rest MBF was 0.73 (0.60-0.91) mL/min·g, stress MBF was 1.72 (1.41-2.10) mL/min·g, and MBFR was 2.31 (1.96-2.74). Across all ages, males augmented MBF in response to vasodilator stress to a greater degree than females but achieved lower absolute stress MBF. Younger males in particular achieved a higher MBFR than their female counterparts, and this gap narrowed with increasing age. Predicted MBFR for a 20-year-old male was 3.18 and female was 2.50, while predicted MBFR for an 80-year-old male was 2.17 and female was 2.02. Conclusions: In patients without demonstrable coronary artery disease, MBFR is higher in younger males than younger females and decreases with age in both sexes. Age- and sex-specific MBFR may be important in risk prediction and guidance for revascularization and warrant further study. Competing Interests: Dr Bateman has received research grant support from Bracco, GE Healthcare, Jubilant Drax Image, and Spectrum Dynamics; has served as a consultant to GE Healthcare and Synektik; and has an equity interest in Cardiovascular Imaging Technologies. The other authors report no conflicts.
Databáze:	MEDLINE
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