Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials.

Autor: Kuang YH; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.; China Dermatologist Association, China.; Chinese Society of Dermatology, China., Zhu W; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.; China Dermatologist Association, China.; Chinese Society of Dermatology, China., Lin G; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.; National Engineering Research Center of Human Stem Cell, Changsha, China., Cheng LM; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.; National Engineering Research Center of Human Stem Cell, Changsha, China., Qin Q; The Office of Drug Clinical Trials Institution, Xiangya Hospital, Central South University, Changsha, China., Huang ZJ; Center for Clinical Pharmacology, The Third Xiangya Hospital of Central South University, Changsha, China., Shi YL; China Dermatologist Association, China.; Chinese Society of Dermatology, China.; Department of Dermatology, Shanghai Skin Disease Hospital, Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China., Zhang CL; China Dermatologist Association, China.; Chinese Society of Dermatology, China.; Department of Dermatology, Peking University Third Hospital, Beijing, China., Xu JH; China Dermatologist Association, China.; Chinese Society of Dermatology, China.; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China., Yan KX; China Dermatologist Association, China.; Chinese Society of Dermatology, China.; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China., Lv CZ; China Dermatologist Association, China.; Chinese Society of Dermatology, China.; Department of Dermatology, Dalian Dermatosis Hospital, Dalian, China., Li W; Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.; China Dermatologist Association, China.; Chinese Society of Dermatology, China., Han Q; International Society on Aging and Disease, Fort Worth, TX, USA.; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.; Center for Excellence in Tissue Engineering, Chinese Academy of Medical Sciences, Beijing, China.; Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy (BZ0381), Beijing, China., Stambler I; International Society on Aging and Disease, Fort Worth, TX, USA.; Department of Science, Technology and Society, Bar Ilan University, Ramat Gan, Israel., Lim LW; International Society on Aging and Disease, Fort Worth, TX, USA.; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China., Chakrabarti S; International Society on Aging and Disease, Fort Worth, TX, USA.; Maharishi Markandeshwar Deemed University, Mullana-Ambala, India., Ulfhake B; International Society on Aging and Disease, Fort Worth, TX, USA.; Karolinska University Hospital, Stockholm, Sweden., Min KJ; International Society on Aging and Disease, Fort Worth, TX, USA.; Department of Biological Sciences, Inha University, Incheon, Republic of Korea., Ellison-Hughes G; International Society on Aging and Disease, Fort Worth, TX, USA.; School of Basic and Medical Biosciences, Faculty of Life Sciences &;amp Medicine, King's College London, London, UK., Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China., Jin K; International Society on Aging and Disease, Fort Worth, TX, USA.; University of North Texas Health Science Center, Bryan, TX, USA., Yao D; Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China., Lu C; Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China.; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, China., Zhao RC; International Society on Aging and Disease, Fort Worth, TX, USA.; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.; Center for Excellence in Tissue Engineering, Chinese Academy of Medical Sciences, Beijing, China.; Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy (BZ0381), Beijing, China., Chen X; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.; China Dermatologist Association, China.; Chinese Society of Dermatology, China.
Jazyk: angličtina
Zdroj: Aging and disease [Aging Dis] 2024 Jun 23. Date of Electronic Publication: 2024 Jun 23.
DOI: 10.14336/AD.2024.0012
Abstrakt: Psoriasis is an immune-mediated, chronic, relapsing, inflammatory, systemic disease induced by individual-environmental interactions, and is often lifelong because of the difficulty of treatment. In recent years, a variety of targeted therapies, including biologics, have improved the lesions and quality of life of most psoriasis patients, but they still do not address the problem of relapse and may be associated with decreased efficacy or adverse events such as infections over time. Therefore, there is an urgent need for breakthroughs in psoriasis treatment and in relapse-delaying and non-pharmacologic strategies, and stem cell therapy for psoriasis has emerged. In recent years, research on stem cell therapy for psoriasis has received a lot of attention, however, there is no reference standard as well as consensus in this field of research. Therefore, according to the latest consensus and guidelines, combined with relevant literature reports, clinical practice experience and the results of discussions with experts, this consensus specifies the types of stem cells commonly used in the treatment of psoriasis, the methods, dosages, and routes of stem cell therapy for psoriasis, as well as the clinical evaluations (efficacy and safety) of stem cell therapy for psoriasis. In addition, this consensus also provides normative standards for the processes of collection, preparation, preservation and quality control of stem cells and their related products, as well as recommendations for the management of stem cells during infusion for the treatment of psoriasis. This consensus provides the latest specific reference standards and practice guidelines for the field of stem cell therapy for psoriasis.
Databáze: MEDLINE