Optimization of atorvastatin and quercetin-loaded solid lipid nanoparticles using Box-Behnken design.

Autor: Lalchandani DS; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India., Chenkual L; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India., Sonpasare K; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India., Rajdev B; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India., Naidu V; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India., Chella N; Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India., Porwal PK; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research-Guwahati (NIPER-G), Changsari, Guwahati, Assam 781101, India.
Jazyk: angličtina
Zdroj: Nanomedicine (London, England) [Nanomedicine (Lond)] 2024 Jul 14; Vol. 19 (17), pp. 1541-1555. Date of Electronic Publication: 2024 Jul 16.
DOI: 10.1080/17435889.2024.2364585
Abstrakt: Aim: The study explores the synergistic potential of atorvastatin (ATR) and quercetin (QUER)- loaded solid lipid nanoparticles (SLN) in combating breast cancer. Materials & methods: SLNs were synthesized using a high-shear homogenization method and optimized using Box-Behnken design. The SLNs were characterized and evaluated for their in vitro anticancer activity. Results: The optimized SLN exhibited narrow size distribution (PDI = 0.338 ± 0.034), a particle size of 72.5 ± 6.5 nm, higher entrapment efficiency (<90%), sustained release and spherical surface particles. The in vitro cytotoxicity studies showed a significant reduction in IC 50 values on MDA-MB-231 cell lines. Conclusion: We report a novel strategy of repurposing well-known drugs and encapsulating them into SLNs as a promising drug-delivery system against breast cancer.
Databáze: MEDLINE
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