Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR).

Autor: Deshmukh H; Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK.; University of Hull, Hull, UK., Ssemmondo E; Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK.; University of Hull, Hull, UK., Adeleke K; Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK.; University of Hull, Hull, UK., Mongolu S; Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK., Aye M; Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK., Orme S; Leeds Teaching Hospitals NSH Trust, Leeds, UK., Flanagan D; University Hospitals Plymouth NHS Trust, Plymouth, UK., Abraham P; NHS Grampian, Aberdeen, UK., Higham C; Department of Endocrinology, Christie Hospital NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Manchester, UK., Sathyapalan T; Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK.; University of Hull, Hull, UK.
Jazyk: angličtina
Zdroj: Clinical endocrinology [Clin Endocrinol (Oxf)] 2024 Sep; Vol. 101 (3), pp. 274-281. Date of Electronic Publication: 2024 Jul 16.
DOI: 10.1111/cen.15112
Abstrakt: Objective: This study aimed to understand the effect of time to remission of acromegaly on survival in people living with acromegaly.
Design, Patients and Measurement: This cross-sectional study used data from the UK Acromegaly Register. We considered remission of acromegaly growth hormone controlled at ≤2 μg/L following the diagnosis of acromegaly. We used the accelerated failure time model to assess the effect of time to remission on survival in acromegaly.
Results: The study population comprises 3569 individuals with acromegaly, with a median age of diagnosis of 47.3 (36.5-57.8) years, 48% females and a majority white population (61%). The number of individuals with the first remission of acromegaly was 2472, and the median time to first remission was 1.92 (0.70-6.58) years. In this study, time to first remission in acromegaly was found to have a significant effect on survival (p < .001); for every 1-year increase in time to first remission, there was a median 1% reduction in survival in acromegaly. In an analysis adjusted for covariates, the survival rate was 52% higher (p < .001) in those who underwent surgery as compared to those who did not have surgery, 18% higher (p = .01) in those who received treatment with somatostatin analogues (SMA) as compared to those with dopamine agonists and 21% lower (p < .001) in those who received conventional radiotherapy as compared to those who did not receive radiotherapy.
Conclusion: In conclusion, this population-based study conducted in patients with acromegaly revealed that faster remission time, surgical intervention and treatment with SMA are linked to improved survival outcomes.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: