Independent inheritance of cognition and bipolar disorder in a family sample.

Autor: D'Amico A; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Sung H; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Arbona-Lampaya A; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Freifeld A; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Hosey K; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Garcia J; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Lacbawan L; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Besançon E; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Kassem L; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Akula N; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., Knowles EEM; Harvard Medical School, Boston, Massachusetts, USA., Dickinson D; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA., McMahon FJ; Intramural Research Program, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, USA.
Jazyk: angličtina
Zdroj: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2024 Jul 16, pp. e33001. Date of Electronic Publication: 2024 Jul 16.
DOI: 10.1002/ajmg.b.33001
Abstrakt: Cognitive deficits in people with bipolar disorder (BD) may be the result of the illness or its treatment, but they could also reflect genetic risk factors shared between BD and cognition. We investigated this question using empirical genetic relationships within a sample of patients with BD and their unaffected relatives. Participants with bipolar I, II, or schizoaffective disorder ("narrow" BD, n = 69), related mood disorders ("broad" BD, n = 135), and their clinically unaffected relatives (n = 227) completed five cognitive tests. General cognitive function (g) was quantified via principal components analysis (PCA). Heritability and genetic correlations were estimated with SOLAR-Eclipse. Participants with "narrow" or "broad" diagnoses showed deficits in g, although affect recognition was unimpaired. Cognitive performance was significantly heritable (h 2  = 0.322 for g, p < 0.005). Coheritability between psychopathology and g was small (0.0184 for narrow and 0.0327 for broad) and healthy relatives of those with BD were cognitively unimpaired. In this family sample, cognitive deficits were present in participants with BD but were not explained by substantial overlaps in genetic determinants of mood and cognition. These findings support the view that cognitive deficits in BD are largely the result of the illness or its treatment.
(© 2024 The Author(s). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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