The Incidence of Breast Cancer Lymph Node Involvement in Trinidad and Tobago.

Autor:	Maharaj A; Internal Medicine, Port of Spain General Hospital, Port of Spain, TTO., Olivers K; Emergency, Eric Williams Medical Sciences Complex, Tacarigua, TTO., Mohammed R; Internal Medicine, Port of Spain General Hospital, Port of Spain, TTO., Ramcharan L; Internal Medicine, Port of Spain General Hospital, Port of Spain, TTO., Deyalsingh V; Internal Medicine, Port of Spain General Hospital, Port of Spain, TTO., Mahase T; Ophthalmology, Port of Spain General Hospital, Port of Spain, TTO., Barrow M; Pathology, Port of Spain General Hospital, Port of Spain, TTO., Barrow S; Pathology, Port of Spain General Hospital, Port of Spain, TTO., Cabral R; General Surgery, Port of Spain General Hospital, Port of Spain, TTO., Lutchman B; General Surgery, Port of Spain General Hospital, Port of Spain, TTO.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 14; Vol. 16 (6), pp. e62406. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).
DOI:	10.7759/cureus.62406
Abstrakt:	Objective This study aims to investigate breast cancer lymph node involvement in a West Indian population while correlating it with various histological parameters and evaluating the role of the sentinel lymph node biopsy. Method This is a retrospective study where histology reports for all breast cancer-related biopsies from 2018 to 2021, totaling 813 samples, were obtained. Histological parameters from these reports were extracted into a spreadsheet and analyzed using Statistical Product and Service Solutions (SPSS, version 28.0; IBM SPSS Statistics for Windows, Armonk, NY) software for TNM staging and axillary and sentinel lymph node dissections, among other fields found in histology reports. Results In 44.8% of cases, patients present at the T2 stage with associated lymph node spread. Each T stage had more lymph nodes involved than uninvolved for tumors sized T2 and higher. Inversely, for tumors staged under T2, there were generally more uninvolved lymph nodes than involved ones. Larger tumors were found to have advanced N staging, especially in the T3 category, where a significantly higher proportion of cases were found to have N2 and N3 staging compared to the other T stages. This trend is also seen in M staging, where larger tumors metastasize more than smaller tumors (40% for T4a, 0% for T1). Despite significant lymph node involvement being observed, sentinel lymph node biopsies were usually negative. Conclusion More patients in this population present with lymph node involvement than without. Larger breast cancer tumors are associated with greater lymph node involvement, particularly at T2 and higher stages. Sentinel lymph node biopsies can be omitted in smaller breast cancer tumors up to 2 cm in size, and the local recurrence rate is low despite a false-negative rate of around 10% in upfront sentinel lymph node biopsy. Competing Interests: Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Maharaj et al.)
Databáze:	MEDLINE
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