An Unusual Case of Lynch Syndrome.
| Autor: | Pinheiro Duque R; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT., Santos N; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT., Freire B; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT., Oliveira CM; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT., Mendes JM; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT., Macedo JP; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT., Sampaio F; General Surgery, Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, PRT. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jun 15; Vol. 16 (6), pp. e62420. Date of Electronic Publication: 2024 Jun 15 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.62420 |
| Abstrakt: | Lynch syndrome is the most common cause of hereditary colorectal cancer. It usually develops asymptomatically until symptoms related to colorectal carcinoma appear, such as gastrointestinal bleeding, abdominal pain, and changes in bowel habits and/or stool characteristics. Oftentime, when these clinical signs and symptoms are not present, the diagnosis becomes challenging. We present the clinical case of a 69-year-old woman, adopted, with no known previous history, who presented to the emergency department with low back pain, without irradiation, that had been going on for three days, associated with inflammatory signs in the right hip region. There were no urinary or sensory alterations and no recent trauma. She was initially discharged with antibiotherapy with the diagnosis of hip cellulitis. As the symptoms continued and the inflammation spread to the right lower limb, she returned to the emergency department. A CT scan revealed an abscess (17 cm) in the right buttock, complicated by necrotizing fasciitis due to fistulization from a tumor in the right colon. She underwent an exploratory laparotomy, which identified a neoplasm of the ascending colon, adherent to the abdominal wall, in the right lumbar region. Right hemicolectomy and drainage of the right buttock/thigh abscess were performed. The histology was compatible with invasive adenocarcinoma, with high-grade dysplasia but well differentiated, pT3G1N0. The immunohistochemistry was suggestive of Lynch syndrome. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Pinheiro Duque et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|