Roles of lipid mediators in early pregnancy events.

Autor: Aikawa S; Department of Obstetrics and Gynecology Graduate School of Medicine, The University of Tokyo Tokyo Japan., Hirota Y; Department of Obstetrics and Gynecology Graduate School of Medicine, The University of Tokyo Tokyo Japan.
Jazyk: angličtina
Zdroj: Reproductive medicine and biology [Reprod Med Biol] 2024 Jul 15; Vol. 23 (1), pp. e12597. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024).
DOI: 10.1002/rmb2.12597
Abstrakt: Background: Early pregnancy events, including embryo implantation, are critical for maintaining a healthy pregnancy and facilitating childbirth. Despite numerous signaling pathways implicated in establishing early pregnancy, a comprehensive understanding of implantation remains elusive.
Methods: This paper provides a comprehensive review of the current research on lipids in the context of early pregnancy, with a particular focus on feto-maternal communications.
Main Findings: Embryo implantation entails direct interaction between uterine tissues and embryos. Introducing embryos triggers significant changes in uterine epithelial morphology and stromal differentiation, facilitating embryo implantation through communication with uterine tissue. Studies employing genetic models and chemical compounds targeting enzymes and receptors have elucidated the crucial roles of lipid mediators-prostaglandins, lysophosphatidic acid, sphingosine-1-phosphate, and cannabinoids-in early pregnancy events.
Conclusion: Given the high conservation of lipid synthases and receptors across species, lipid mediators likely play pivotal roles in rodents and humans. Further investigations into lipids hold promise for developing novel diagnostic and therapeutic approaches for infertility in humans.
Competing Interests: The authors declare no conflicts of interest.
(© 2024 The Author(s). Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.)
Databáze: MEDLINE
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