CD3 + TCRαβ/CD19 + -depleted stem cell boost and CD45RO + memory T-cell add-back as a successful salvage treatment for poor graft function unresponsive to eltrombopag, following a second allogenic HSCT.

Autor: Ramanathan S; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Roberts W; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nademi Z; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Shenton G; Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Watson H; Blood Sciences, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK., Matthews E; Newcastle Advanced Therapies, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK., Carruthers K; Newcastle Advanced Therapies, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK., Gennery AR; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Hambleton S; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Slatter M; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Lum SH; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Oct; Vol. 71 (10), pp. e31203. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1002/pbc.31203
Databáze: MEDLINE