Computational estimation of clonal diversity in autoimmunity.

Autor: Tuong ZK; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., van der Merwe R; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Canete PF; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia., Roco JA; Biological Data Science Institute, College of Science, The Australian National University, Canberra, ACT, Australia.; Clinical Hub for Interventional Research, College of Health & Medicine, The Australian National University, Canberra, ACT, Australia.
Jazyk: angličtina
Zdroj: Immunology and cell biology [Immunol Cell Biol] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1111/imcb.12801
Abstrakt: Diversity is the cornerstone of the adaptive immune system, crucial for its effectiveness against constantly evolving pathogens that pose threats to higher vertebrates. Accurately measuring and interpreting this diversity presents challenges for immunologists, as changes in diversity and clonotype composition can tip the balance between protective immunity and autoimmunity. In this review, we present the current methods commonly used to measure diversity from single-cell T-cell receptor and B-cell receptor sequencing. We also discuss two case studies where single-cell sequencing and diversity estimations have led to breakthroughs in autoimmune disease discovery and therapeutic innovation, and reflect upon the necessity and importance of accurately defining and measuring lymphocyte diversity in these contexts.
(© 2024 The Author(s). Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.)
Databáze: MEDLINE
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