Differential Expression of mRNA in Peripheral Blood Mononuclear Cells May Predict Postoperative Atrial Fibrillation in Coronary Artery Bypass Surgery Patients.

Autor: Tan M; Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.; Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China., Liu X; Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Institute of Cardiovascular Diseases, Chest Hospital, Tianjin University, Tianjin, China., Wang L; Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China., Jiang N; Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China., Bai Y; Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China. oliverwhite@126.com.; Clinical School of Thoracic, Tianjin Medical University, Tianjin, China. oliverwhite@126.com.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China. oliverwhite@126.com., Guo Z; Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China. zhigangguo2022@126.com.; Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China. zhigangguo2022@126.com.; Clinical School of Thoracic, Tianjin Medical University, Tianjin, China. zhigangguo2022@126.com.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China. zhigangguo2022@126.com.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2024 Oct; Vol. 17 (5), pp. 1193-1204. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1007/s12265-024-10524-8
Abstrakt: Postoperative Atrial Fibrillation (POAF) frequently follows Coronary Artery Bypass Grafting (CABG) surgery. This prospective study investigates genes linked to POAF in CABG patients, aiming to create a predictive model. Employing differential gene and methylation analyses, the study identified four genes (WARS2, CKAP2, CHI3L1, HSD17B6) associated with POAF. Preoperative plasma samples and clinical data were collected from 139 CABG patients, categorized into POAF (+) (43) and POAF (-) (96). Real-time quantitative PCR assessed gene expression, and a predictive model using the LASSO method demonstrated robust performance, with AUC values of 0.8895 in the training set and 0.7840 in the test set. This pioneering study integrates genomics and clinical data, suggesting WARS2, CKAP2, and CHI3L1 as potential indicators for POAF prediction.
(© 2024. The Author(s).)
Databáze: MEDLINE
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