Type I interferon induced during chronic viral infection favors B-cell development in the thymus.

Autor: Valbon SF; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada.; Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.; Department of Microbiology, Immunology and Infectious Disease, University of Montreal, Montreal, QC, Canada., Lebel ME; Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada., Feldman HA; Center for Autoimmune Genomics & Etiology, Division of Human Genetics, Cincinnati Children's Hospital, Cincinnati, OH, USA.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Condotta SA; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada.; Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.; Cooperative Center for Excellence in Hematology, Indiana University School of Medicine, Indianapolis, IN, USA.; Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA., Dong M; Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada., Giordano D; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA., Waggoner SN; Center for Autoimmune Genomics & Etiology, Division of Human Genetics, Cincinnati Children's Hospital, Cincinnati, OH, USA.; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Melichar HJ; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada.; Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.; Département de Médecine, Université de Montréal, Montréal, QC, Canada., Richer MJ; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada.; Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.; Cooperative Center for Excellence in Hematology, Indiana University School of Medicine, Indianapolis, IN, USA.; Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Jazyk: angličtina
Zdroj: Immunology and cell biology [Immunol Cell Biol] 2024 Oct; Vol. 102 (9), pp. 801-816. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1111/imcb.12808
Abstrakt: Chronic viral infections cause thymic involution yet the potential for broader, longer-term impact on thymic composition remains unexplored. Here we show that chronic, but not acute, lymphocytic choriomeningitis virus infection promotes a unique population of immature B cells in the thymus. We show that chronic viral infection promotes signals within the thymus, including the expression of B-cell activating factor (BAFF), that favor the maturation of this population as these cells acquire expression of CD19 and immunoglobulin M. Mechanistically, type I interferon (IFN-I), predominantly IFNβ, signals to thymic hematopoietic cells, strongly delaying T-cell development at the earliest precursor stage. Furthermore, IFN-I signaling to the nonhematopoietic compartment provides a second signal essential to favor B-cell differentiation and maturation within the thymus. Importantly, chronic infection yields changes in the B-cell population for at least 50 days following infection, long after thymic atrophy has subsided. Thus, the inflammatory milieu induced by chronic viral infection has a profound, and long-lasting, effect on thymic composition leading to the generation of a novel population of thymic B cells.
(© 2024 The Author(s). Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.)
Databáze: MEDLINE
Externí odkaz: