Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study.

Autor: Gebreyohannes EA; Quality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia. eyob.gebreyohannes@unisa.edu.au.; School of Allied Health, The University of Western Australia, Perth, Australia. eyob.gebreyohannes@unisa.edu.au.; Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, The University of Aberdeen, Aberdeen, UK. eyob.gebreyohannes@unisa.edu.au., Shibe BS; Department of Clinical Pharmacy, School of Pharmacy, University of Gondar, Gondar, Ethiopia., Taye WA; Department of Clinical Pharmacy, School of Pharmacy, University of Gondar, Gondar, Ethiopia., Lee K; School of Allied Health, The University of Western Australia, Perth, Australia., Abdela OA; Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, The University of Aberdeen, Aberdeen, UK.; Department of Clinical Pharmacy, School of Pharmacy, University of Gondar, Gondar, Ethiopia., Ayele EM; Department of Clinical Pharmacy, School of Pharmacy, University of Gondar, Gondar, Ethiopia., Belachew EA; Department of Clinical Pharmacy, School of Pharmacy, University of Gondar, Gondar, Ethiopia., Mengistu SB; Department of Internal Medicine, School of Medicine, University of Gondar, Gondar, Ethiopia., Myint PK; Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, The University of Aberdeen, Aberdeen, UK., Soiza RL; Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, The University of Aberdeen, Aberdeen, UK.
Jazyk: angličtina
Zdroj: International journal of clinical pharmacy [Int J Clin Pharm] 2024 Dec; Vol. 46 (6), pp. 1352-1361. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1007/s11096-024-01769-z
Abstrakt: Background: Anticholinergic medications are now widely acknowledged for their unfavorable risk-to-benefit profile owing to their adverse effects. Health-related quality of life (HRQoL) is commonly regarded as a crucial person-centered outcome.
Aim: This study aimed to investigate the association between anticholinergic burden and HRQoL in hospitalized and ambulatory patients seen in Ethiopia.
Method: This cross-sectional study utilized a questionnaire and medical records to collect data from a convenience sample of adult patients attending both inpatient wards and ambulatory clinic of University of Gondar Comprehensive Specialized Hospital between April and September 2022. Anticholinergic burden was measured by anticholinergic cognitive burdens scale (ACBS), while HRQoL was measured using EQ5D-index (Euroqol-5 dimensions-5-Levels index) and EQ5D-VAS (visual analogue scale). Linear regression was used to assess the influence of high anticholinergic burden (ACBS score ≥ 3) on EQ5D-index and EQ5D-VAS, with adjustments made for sociodemographic and clinical confounders.
Results: A total of 828 patients participated in this study (median (IQR) age was 45.0 (30, 60) and 55.9% were female). On multiple linear regression analysis, high anticholinergic burden was associated with a statistically significant decline in HRQoL, as evidenced by reductions in both EQ5D index (- 0.174 (- 0.250, - 0.098)) and EQ5D-VAS scores (- 9.4 (- 13.3, - 5.2)).
Conclusion: A significant association between high anticholinergic burden and diminished HRQoL was found among a relatively younger cohort in a resource-limited setting, even after adjustment for important confounding variables. Clinicians should be cognizant of the cumulative impact of anticholinergic burden on HRQoL outcomes and strive to minimize anticholinergic burden.
Competing Interests: Conflicts of interest There are no conflicts of interest declared by the authors.
(© 2024. The Author(s).)
Databáze: MEDLINE
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