A systematic review of MRI studies on the effects of maternal obesity on offspring brain structure and function.

Autor: Parsaei M; Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Hashemi SM; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Moghaddam HS; Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran., Peterson BS; Institute for the Developing Mind, Children's Hospital, Los Angeles, California, USA.; Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2024 Jul; Vol. 102 (7), pp. e25368.
DOI: 10.1002/jnr.25368
Abstrakt: Maternal obesity before or during pregnancy has been associated previously in offspring with a wide range of poor neurodevelopmental outcomes and mental health problems. The effects of maternal obesity on offspring brain structure and function that may be responsible for these poor outcomes are not well understood. We, therefore, undertook a systematic review of magnetic resonance imaging (MRI) studies that have assessed the associations of maternal obesity with brain measures in offspring. A systematic search was conducted in PubMed, Web of Science, Scopus, and PsycINFO on August 20, 2023. Of 15 eligible studies, seven employed functional MRI (fMRI), five diffusion tensor imaging (DTI), and four anatomical MRI (one used both DTI and anatomical MRI) in the offspring. The ages of offspring varied widely: one was a study of fetuses in utero, five of neonates, one of infants, five of school-aged children, two of both neonates and infants, and one of both children and adults. Collectively, 12 studies reported significant associations of maternal obesity with structural or functional alterations of the offspring's brain, most frequently in the prefrontal cortex and limbic system. In conclusion, maternal obesity appears to have a profound influence on offspring brain development, particularly within the prefrontal and limbic networks that regulate emotion and behavior. Further studies are needed to identify how changes in brain structure and function mediate the effects of maternal obesity on long-term emotional and behavioral outcomes, as well as the molecular pathways through which maternal obesity alters offspring brain development.
(© 2024 The Author(s). Journal of Neuroscience Research published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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