Efficacy and Safety of Laser Therapy on Ischemic Central Retinal Vein Occlusion: A Systematic Review and Analysis of Clinical Studies.

Autor:	Alotaibi GF; Faculty of Medicine, Taif University, Taif, SAU., Seraj H; Ophthalmology, King Abdulaziz University, Jeddah, SAU., AlMulihi QA; Emergency, Ministry of Health Holdings, Al Khobar, SAU., Alkhawajah AA; Medicine and Surgery, King Faisal University, Al Ahsa, SAU., Eshbeer SG; Medicine and Surgery, Ibn Sina National College for Medical Studies, Jeddah, SAU., Alghamdi AA; Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, SAU., AlTowairqi AM; Medicine and Surgery, Taif University, Taif, SAU., Aloufi SS; Medicine and Surgery, Taibah University, Madinah, SAU., Alshubayni AM; General Practice, King Faisal Specialist Hospital & Research Centre, Tabuk, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 13; Vol. 16 (6), pp. e62292. Date of Electronic Publication: 2024 Jun 13 (Print Publication: 2024).
DOI:	10.7759/cureus.62292
Abstrakt:	Many studies have evaluated different treatments for ischemic central retinal vein occlusion (CRVO). Nevertheless, improvement and complication rates vary significantly. This systematic review aimed to evaluate the efficacy of laser therapy in treating ischemic CRVO compared with a control group using other treatments. The databases of PubMed, Google Scholar, and ClinicalTrials.gov were searched using a variety of keywords, including "ischemic central retinal vein occlusion," "CRVO," "laser," and "panretinal photocoagulation." After data extraction, each study's quality was assessed using the methodological index for nonrandomized studies (MINORS) or grading of recommendations, assessment, development, and evaluation or GRADE standards. A sum of 195 abstracts were reviewed, and seven clinical trials were eventually chosen. Of these, four were prospective studies, two were randomized controlled studies, and only one was a retrospective study. The assessment of potential biases in our included studies revealed that all these studies demonstrated moderate or high quality. Two studies were selected for meta-analysis, and the results showed no significant difference in visual acuity (VA) outcomes between the treated and the control groups (P = 0.17). In the remaining five studies, laser therapy was found to be more effective at neovascular complications, with a higher rate of neovascular glaucoma (NVG), iris neovascularization (NVI), neovascularisation at disc (NVD), and retinal neovascularization in the group without laser treatments. This review suggests that laser therapy is essential in preventing neovascular complications, such as NVG, NVI, NVD, and retinal neovascularization rather than improving VA. In addition, the combination of laser photocoagulation and intravitreal injection (IVI) improved VA, but further studies are required. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Alotaibi et al.)
Databáze:	MEDLINE
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