Exploring the Therapeutic Potential of Camellia longii Orel & Luu Leaf Extracts for Memory Loss in Alzheimer's Disease: Novel Findings and Functional Food Applications.

Autor:	Anh Phan DT; Faculty of Chemical and Food Technology, HCMC University of Technology and Education, Ho Chi Minh City 700000, Vietnam., Tran HT; Faculty of Chemical and Food Technology, HCMC University of Technology and Education, Ho Chi Minh City 700000, Vietnam., Le HP; College of Science and Engineering, Flinders University, Sturt Rd, Bedford Park, South Australia, 5042, Australia., Khuong TH; Bu Gia Map National Park, Binh Phuoc Province 830000, Vietnam., Ha HT; Faculty of Chemical and Food Technology, HCMC University of Technology and Education, Ho Chi Minh City 700000, Vietnam., Nguyen DT; Faculty of Chemical and Food Technology, HCMC University of Technology and Education, Ho Chi Minh City 700000, Vietnam., Nguyen GT; Faculty of Chemical and Food Technology, HCMC University of Technology and Education, Ho Chi Minh City 700000, Vietnam., Le MV; Research Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials, Ho Chi Minh City 700000, Vietnam., Ly TH; Research Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials, Ho Chi Minh City 700000, Vietnam.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2024 Jun 27; Vol. 9 (27), pp. 29651-29665. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024).
DOI:	10.1021/acsomega.4c02980
Abstrakt:	Novel research on the chemical compositions and biochemical activities of Camellia longii Orel and Luu leaf extracts revealed valuable resources with potential applications in Alzheimer's disease treatment. Qualitative phytochemicals detected various compound groups, including polyphenols, saponins, tannins, flavonoids, alkaloids, amino acids, coumarins, and polysaccharides. HPLC-MS identified 23 compounds in C. longii leaves with compounds found at significant levels, including epicatechin gallate (17.12%), tryptophan (13.73%), isovitexin (12.91%), gallic acid (3.06%), and quercetin (3.06%). Interestingly, the ethanol extract (CLL-Ew) exhibited the highest extraction yield (26.6%) and potent antioxidant and acetylcholinesterase (AChE) inhibitory effects in vitro. In the Drosophila melanogaster model, CLL-Ew improved longevity, movement, and memory by reducing malondialdehyde and increasing glutathione levels. Docking simulations suggested that the above compounds bind tightly to AChE's active site, potentially contributing to memory enhancement. Interestingly, observations of male and female mice after administration of a dose of 5000 mg/kg C. longii leaf extract were recorded normally throughout the 14 day experiment. These findings highlight the potential of C. longii leaf extracts in functional foods and therapeutic interventions for memory impairment prevention and treatment. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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