Effect of Envenomation on Serum Hepatic Biomarkers in Snake (Echis Ocellatus) Bitten Individuals in Zamko Comprehensive Health Centre of the Jos University Teaching Hospital, North Central Nigeria.

Autor:	Longwap A; Department of Chemical Pathology, University of Jos, Jos, Nigeria., Emmanuel I; Department of Histopathology, University of Jos, Jos, Nigeria., Affi A; Department of Chemical Pathology, University of Jos, Jos, Nigeria., Imoh L; Department of Chemical Pathology, University of Jos, Jos, Nigeria., Mbwas M; Department of Histopathology, University of Jos, Jos, Nigeria., Dajel T; Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria., Bawa I; Department of Chemical Pathology, Abubabar Tafawa Balewa University, Bauchi, Nigeria., Sani A; Department of Chemical Pathology, Federal Teaching Hospital Gombe, Nigeria., Akpagher F; Department of Histopathology, Bingham University Teaching Hospital, Jos, Nigeria., Odo A; Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria., Isichei C; Department of Chemical Pathology, University of Jos, Jos, Nigeria., Ajang Y; Department of Family Medicine, Jos University Teaching Hospital, Jos, Nigeria., Adebisi S; Department of Chemical Pathology, Benue State University Teaching Hospital, Benue, Nigeria., Salihu F; Departments of Medicine and Surgery, University of Jos, Jos, Nigeria.
Jazyk:	angličtina
Zdroj:	Nigerian medical journal : journal of the Nigeria Medical Association [Niger Med J] 2024 May 23; Vol. 65 (2), pp. 142-152. Date of Electronic Publication: 2024 May 23 (Print Publication: 2024).
DOI:	10.60787/nmj-v65i2-353
Abstrakt:	Background: Snake bite is a neglected public health issue in many tropical and subtropical countries of the world. About 5.4 million snakebites occur each year, resulting in 1.8 to 2.7 million cases of envenomation yearly. Hepatic markers have been reported to rise 3-6 hours after injection of venom in experimental animals. This study aims to biochemically assess ALT, AST and GGT levels as biomarkers of Echis ocellatus envenomation in victims of snake bite presenting at JUTH Comprehensive Health Centre Zamko 6hours post-bite and compare with values in those bitten by non-venomous snakes. Methodology: The study was a comparative cross-sectional study where serum levels of AST, ALT and GGT were compared between the study group and the control group. Results: Of the 150 respondents, 75 from each study group, 90(60.0%) were Male while 60(40.0%) were Female, with a Male to Female ratio of 1.5:1. The most predominant age group was 20-29 years 57(38.0%), the mean age was 39 years. The most predominant occupation was farming 82(54.7%). The majority 82(54.7%) had a secondary level of education. 91(60.7%) were married. A large majority of 123(82.0) had Christianity as their religion. We found a significant increase in the levels of AST (47.45IU/L) and GGT (61.62 IU/L) in the study group compared to AST (25.88IU/L), GGT (29.61IU/L) in the control group at p<0.05, while the level of ALT was similar in both groups at p>0.05. Conclusion: This implies that serum levels of AST and GGT can be used to diagnose envenomation in snakebite patients. Competing Interests: The authors declared that there is no competing interest (Copyright © 2024 Nigerian Medical Association.)
Databáze:	MEDLINE
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