| Autor: |
Gupta AK, Pedroarena J, Nazarian A, Antonova-Koch J, Weiss F, Kumpornsin K, Chi V, Woods AK, Lee KJ, Joseph SB, Li S, Brittain J, De Hostos E, Duffy J, Cooper A, Schultz PG, McNamara CW, Chatterjee AK |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 01. Date of Electronic Publication: 2024 Jul 01. |
| DOI: |
10.1101/2024.07.01.601566 |
| Abstrakt: |
In efforts towards eliminating malaria, a discovery program was initiated to identify a novel antimalarial using KAF156 as a starting point. Following the most recent TCP/TPP guidelines, we have identified mCMQ069 with a predicted single oral dose for treatment (∼40-106 mg) and one-month chemoprevention (∼96-216 mg). We have improved unbound MPC and predicted human clearance by 18-fold and 10-fold respectively when compared to KAF156. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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