Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.

Autor: Lalla RV; Section of Oral Medicine, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA., Helgeson ES; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Virk K; Division of General Dentistry, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA., Lu H; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Treister NS; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA., Sollecito TP; Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA.; Division of Oral Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA., Schmidt BL; Department of Oral & Maxillofacial Surgery and Bluestone Center for Clinical Research, New York University College of Dentistry, New York, New York, USA., Patton LL; Division of Craniofacial and Surgical Care, Adams School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA., Lin A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Brennan MT; Department of Oral Medicine/Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.; Department of Otolaryngology/Head & Neck Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, USA.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1111/odi.15068
Abstrakt: Objective: To compare salivary flow rates between females and males, before and after radiation therapy (RT) for head and neck cancer (HNC).
Methods: Prospective observational multicenter cohort study (OraRad). Stimulated whole salivary flow was measured before RT and at 6 and 18 months after RT.
Results: Mean (95% confidence interval) salivary flow in g/min before RT was 0.81 (0.71, 0.90) in females (n = 107) and 1.20 (1.15, 1.25) in males (n = 391) (p < 0.001); at 6 months was 0.34 (0.24, 0.44) in females and 0.50 (0.44, 0.55) in males (p = 0.01); at 18 months was 0.49 (0.38, 0.59) in females and 0.70 (0.64, 0.75) in males (p < 0.001). Median nadir salivary flow after RT was 0.22 in females and 0.35 in males (p < 0.001). A lower nadir salivary flow in females, but not males, was associated with an increased risk for tooth failure (p = 0.02).
Conclusions: Females with HNC have lower stimulated whole salivary flow than males, before and after RT. Low salivary flow after RT may be a risk factor for tooth failure among females. The lower pre-RT salivary flow rates in females, combined with prior literature in other populations, indicates that, in general, females have lower stimulated salivary flow than males.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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