Inhibitory Activity of Compounds Isolated from Ligustrum robustum (Roxb.) Against HepG2 Liver Cancer Cells: Isocubein and 4-(2-Acetoxyethyl)phenol as Potential Candidates.

Autor: Nong TAT; Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen University, Thai Nguyen, Vietnam., Le TTH; Thai Nguyen University of Sciences, Thai Nguyen University, Thai Nguyen, Vietnam., Vu VT; Faculty of Pharmacy, Phenikaa University, Hanoi, Vietnam., Nguyen MQ; Center for Interdisciplinary Science and Education, Thai Nguyen University, Thai Nguyen, Vietnam., Can DQH; Thai Nguyen University of Sciences, Thai Nguyen University, Thai Nguyen, Vietnam., Dong THY; Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen University, Thai Nguyen, Vietnam., Nguyen TPT; Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen University, Thai Nguyen, Vietnam., Hoang VH; Center for Interdisciplinary Science and Education, Thai Nguyen University, Thai Nguyen, Vietnam., Nguyen PH; Center for Interdisciplinary Science and Education, Thai Nguyen University, Thai Nguyen, Vietnam.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Oct; Vol. 21 (10), pp. e202401065. Date of Electronic Publication: 2024 Sep 06.
DOI: 10.1002/cbdv.202401065
Abstrakt: Many herbal species in the genus Ligustrum have been shown to contain compounds with anti-cancer biological activity. This study aimed to isolate some compounds from the leaves of Ligustrum robustum (Roxb.) Blume (L. robustum) and evaluate their effects against liver cancer cells. As a result, seven previously reported compounds (1-7) were isolated, including four lignans (1-4) and three phenolic derivatives (5-7). The structures of these compounds were determined using spectroscopic methods and comparison with reported data. All isolates were assessed for their inhibitory effects on HepG2 liver cancer cells. Screening results revealed that two compounds, isocubein (3) and 4-(2-acetoxyethyl)phenol (7), exhibited strong inhibitory activity against cell proliferation, with IC 50 values of 3.1±0.9 and 4.5±14 μM, respectively. Further analyses demonstrated that both compounds could suppress the formation and development of 3D tumorspheres in terms of quantity and size. Additionally, isocubein (3) and 4-(2-acetoxyethyl)phenol (7) exhibited the ability to inhibit the migration of HepG2 cells. This study represents the first report on the inhibitory activity against HepG2 liver cancer cells of extracts and isolated compounds from L. robustum, providing valuable information for future research aiming to develop products for liver cancer treatment.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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