Tropospheric ozone effect on olfactory perception and olfactory bulb dopaminergic interneuron excitability.

Autor: Pignatelli A; Dept. of Neuroscience and Rehabilitation, University of Ferrara, Ferrara 44121, Italy. Electronic address: angela.pignatelli@unife.it., Benedusi M; Dept. of Neuroscience and Rehabilitation, University of Ferrara, Ferrara 44121, Italy. Electronic address: mascia.benedusi@unife.it., Barbieri M; Dept. of Neuroscience and Rehabilitation, University of Ferrara, Ferrara 44121, Italy. Electronic address: mario.barbieri@unife.it., Pecorelli A; Dept. of Environmental and Prevention Sciences, University of Ferrara, Ferrara 44121, Italy. Electronic address: alessandra.pecorelli@unife.it., Valacchi G; Dept. of Environmental and Prevention Sciences, University of Ferrara, Ferrara 44121, Italy; Dept. of Animal Sciences, Plants for Human Health Institute, NC Research Campus, NC State University, Kannapolis, NC 28081, USA; Dept. of Food and Nutrition, Kyung Hee University, Seoul 26723, Republic of Korea. Electronic address: giuseppe.valacchi@unife.it.
Jazyk: angličtina
Zdroj: Neurotoxicology [Neurotoxicology] 2024 Sep; Vol. 104, pp. 36-44. Date of Electronic Publication: 2024 Jul 14.
DOI: 10.1016/j.neuro.2024.07.003
Abstrakt: Ozone (O 3 ) forms in the Earth's atmosphere, both naturally and by reactions of man-made air pollutants. Deleterious effects of O 3 have been found in the respiratory system. Here, we examine whether O 3 alters olfactory behavior and cellular properties in the olfactory system. For this purpose, mice were exposed to O 3 at a concentration found in highly polluted city air [0.8 ppm], and the behavior elicited by social and non-social odors in habituation/dishabituation tests was assessed. In addition, the electrical responses of dopaminergic olfactory bulb (OB) neurons were also evaluated. O 3 differentially compromises olfactory perception to odors: it reduces responses to social and non-social odors in Swiss Webster mice, while this effect was observed in C57BL/6 J mice only for some non-social odors. Additionally, O 3 reduced the rate of spontaneous spike firing in periglomerular dopaminergic cells (PG-DA) of the OB. Because this effect could reflect changes in excitability and/or synaptic inputs, the ability of O 3 to alter PG-DA spontaneous activity was also tested together with cell membrane resistance, membrane potential, rheobase and chronaxie. Taken together, our data suggest the ability of O 3 to affect olfactory perception.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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