Frailty and all-cause and cancer-related mortality in cancer patients: A prospective cohort study.

Autor: Hu FH; School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China., Feng LP; Family-Centered Maternity Ward, Affiliated Hospital of Nantong University, Nantong University, Nantong, Jiangsu, China., Jia YJ; School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China., Ge MW; School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China., Shen LT; School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China., Liu P; School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China. Electronic address: Lp2001@ntu.edu.cn., Chen HL; School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China. Electronic address: honglinyjs@126.com.
Jazyk: angličtina
Zdroj: European journal of oncology nursing : the official journal of European Oncology Nursing Society [Eur J Oncol Nurs] 2024 Aug; Vol. 71, pp. 102667. Date of Electronic Publication: 2024 Jul 13.
DOI: 10.1016/j.ejon.2024.102667
Abstrakt: Purpose: To evaluate the associations between frailty and all-cause and cancer-related mortality. Additionally, the objective is to compare the magnitude of these associations between older adults and younger adults.
Methods: We gathered baseline data from NHANES (1999-2018) and developed a cumulative index consisting of 39 items to evaluate frailty. The National Death Index database was utilized to track the survival status of individuals. The Cox regression model was employed to estimate the associations between frailty status and all-cause and cancer-related mortality.
Results: Ultimately, 3398 cancer patients were included in the analysis, comprising 910 younger adults and 2488 older adults. Compared to non-frail patients, the elevated all-cause and cancer-related mortality among pre-frail patients was not statistically significant (HRs = 1.312, 95%CI: 0.956-1.800, P = 0.092; HRs = 1.462, 0.811-2.635, P = 0.207). However, a significant elevation of both all-cause and cancer-related mortality risk was observed among frail patients (HRs = 2.213, 1.617-3.030, P < 0.001; HRs = 2.463, 95%CI = 1.370-4.429, P = 0.003). Frailty individuals demonstrated a more pronounced association with the prediction of all-cause mortality in younger (HRs = 2.230, 1.073-4.634, P = 0.032) than in older adults (HRs = 2.090, 1.475-2.960, P < 0.001). Sensitivity analysis consistently revealed robust results. RCS plots suggested a progressively escalating dose-response correlation between frailty and both all-cause and cancer-related mortality risk.
Conclusions: Pre-frailty did not result in an increase in mortality risks compared to non-frailty. However, frailty caused a higher all-cause and cancer-related mortality risk than non-frailty. Identifying those at risk and implementing targeted interventions may contribute to extending healthy life expectancy, regardless of age.
Competing Interests: Declaration of competing interest All authors report no conflicts of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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