Chirality identification of Ibuprofen enantiomers by a terahertz polarization-sensitive metasurface sensor.

Autor: Yang J; GBA branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510700, China; School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China; Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou 510700, China., Wang T; GBA branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510700, China; Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou 510700, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: wangtw@aircas.ac.cn., Fang G; GBA branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510700, China; Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou 510700, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: gyfang@mail.ie.ac.cn., Qi L; School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China. Electronic address: qilimei1204@163.com., Chen X; GBA branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510700, China; Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou 510700, China., Zhou H; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou 510095, China. Electronic address: zhouhuaping_vip020@163.com.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Dec 05; Vol. 322, pp. 124803. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1016/j.saa.2024.124803
Abstrakt: Chirality plays an important role in medicine, biology, and chemistry. Molecules of different chirality could display dramatically different medical effects, pharmacological activities, and physiological impacts. Ibuprofen is an important anti-inflammatory drug in clinics. The anti-inflammatory effect is almost solely attributed to the (S)-(+)-Ibuprofen, while its enantiomer (R)-(-)-Ibuprofen plays a negative effect on increasing the metabolic burden. In this work, a terahertz (THz) polarization-sensitive metasurface sensor is proposed for qualitative and quantitative identification of the chiral Ibuprofen. The chirality parameters of Ibuprofen are extracted from the circular-polarized transmission coefficients. The parameters are further used to simulate the coupling mechanism between the Ibuprofen and the sensor to explain the principle of recognition. The sensitivities of (R)-(-)-Ibuprofen and (S)-(+)-Ibuprofen are found to be 1.5 THz/(mg/L) and 1.8 THz/(mg/L) for the TM polarization, respectively, and 1.7 THz/(mg/L) and 2.1 THz/(mg/L) for the TE polarization, respectively. The difference enables the chirality identification according to the different frequency shift at the same concentration. The exceptional specificity and sensitivity provide a new avenue for chiral molecular recognition.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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