Identification and characterization of TM4SF1 + tumor self-seeded cells.

Autor:	Yang H; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia; Gallipoli Medical Research, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia., Wang H; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia; Gallipoli Medical Research, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia., He Y; Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia., Yang Y; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Thompson EW; School of Biomedical Sciences, Queensland University of Technology and Translational Research Institute, Brisbane, QLD 4000, Australia., Xia D; Genome Innovation Hub, The University of Queensland, Brisbane, QLD 4072, Australia., Burke LJ; Gallipoli Medical Research, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia., Cao L; Gallipoli Medical Research, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia., Hooper JD; Mater Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia., Roberts MS; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Crawford DHG; Gallipoli Medical Research, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4006, Australia., Liang X; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia; Gallipoli Medical Research, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia. Electronic address: x.liang@uq.edu.au.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114512. Date of Electronic Publication: 2024 Jul 13.
DOI:	10.1016/j.celrep.2024.114512
Abstrakt:	Tumor self-seeding is a process whereby circulating tumor cells (CTCs) recolonize the primary tumor, which promotes tumor growth, angiogenesis, and invasion. However, the detailed nature and functions of tumor self-seeded cells (TSCs) have not been well defined due to challenges in tracking and isolating TSCs. Here, we report an accurate animal model using photoconvertible tagging to recapitulate the spontaneous process of tumor self-seeding and identify TSCs as a subpopulation of primary tumor cells with enhanced invasiveness and survival. We demonstrate transmembrane-4-L-six-family-1 (TM4SF1) as a marker of TSCs, which promotes migration, invasion, and anchorage-independent survival in cancer cells. By analyzing single-cell RNA sequencing datasets, we identify a potential TSC population with a metastatic profile in patients with cancer, which is detectable in early-stage disease and expands during cancer progression. In summary, we establish a framework to study TSCs and identify emerging cell targets with diagnostic, prognostic, or therapeutic potential in cancers. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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