Altered tumor microenvironment heterogeneity of penile cancer during progression from non-lymphatic to lymphatic metastasis.

Autor: Xu DM; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Zhuang XY; Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, P. R. China., Ma HL; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Li ZS; Department of Urology, Shenzhen People's Hospital, The Second Clinic Medical College of Jinan University, Shenzhen, P. R. China., Wei LC; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Luo JH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.; Institute of Precision Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China., Han H; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2024 Jul; Vol. 13 (14), pp. e70025.
DOI: 10.1002/cam4.70025
Abstrakt: Background: Lymphatic metastasis is the major challenge in the treatment of penile cancer. The prognosis of individuals with lymphatic metastasis is extremely poor. Therefore, early identification of disease progression and lymphatic metastasis is an urgent task for researchers in penile cancer worldwide.
Methods: In this study, using single-cell RNA sequencing, an immune landscape was established for the cancer ecosystem based on 46,861 cells from six patients with penile cancer (four with lymphatic metastasis [stage IV] and two without lymphatic metastasis [stage I]). Using bulk RNA sequencing, the discrepancy between the cancers and their respective metastatic lymph nodes was depicted based on seven patients with penile cancer.
Results: The interaction between epithelial cells, fibroblasts, and endothelial cells, and the functional cooperation among invasion, epithelial-mesenchymal transition, and angiogenesis were found to be important landscapes in the penile cancer ecosystem, playing important roles in progression of cancer and lymph node metastasis.
Conclusions: This study is the first to investigate the altered tumor microenvironment heterogeneity of penile cancer as it evolves from non-lymphatic to lymphatic metastasis and provides insights into the mechanisms underlying malignant progression, the premetastatic niche, and lymphatic metastasis in penile cancer.
(© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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