The addition of mycoprotein to a mixed-meal impacts postprandial glucose kinetics without altering blood glucose concentrations: a randomised controlled trial.
Autor: | Whelehan G; Department of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK., West S; Department of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK., Abdelrahman DR; Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.; Sealy Center of Aging, University of Texas Medical Branch, Galveston, TX, USA., Murton AJ; Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.; Sealy Center of Aging, University of Texas Medical Branch, Galveston, TX, USA., Finnigan TJA; New Era Foods, Hutton Rudby, Yarm, TS15 0JZ, UK., Wall BT; Department of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK., Stephens FB; Department of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK. f.b.stephens@exeter.ac.uk. |
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Jazyk: | angličtina |
Zdroj: | European journal of clinical nutrition [Eur J Clin Nutr] 2024 Sep; Vol. 78 (9), pp. 757-764. Date of Electronic Publication: 2024 Jul 13. |
DOI: | 10.1038/s41430-024-01470-4 |
Abstrakt: | Background: Mycoprotein is a high-fibre food previously shown to reduce postprandial glucose concentrations when ingested within a mixed-meal. We applied a dual stable isotope tracer approach to determine whether this is due to a reduced rate of appearance of glucose, in participants of ranging BMI. Methods: Twenty-four adults (F = 8, BMI 30 ± 6 kg·m -2 ) attended 2 trials in a double-blind, randomised, cross-over design. Participants ingested two energy and macronutrient matched milk-based drinks (enriched with 1000 mg [U- 13 C Results: Drink ingestion increased blood glucose and serum insulin concentrations (P < 0.05) and were comparable between conditions (P > 0.05). Both RaT and RdT were higher with MYC compared with CON over 6 h (mean 6 h glucose appearance and disappearance increased by 5 and 9%, respectively, P < 0.05). RaEx was not affected by MYC ingestion over 6 h (P > 0.05). The mean contribution of EGP to total glucose appearance was 15% greater with MYC, with a trend towards significance (P = 0.05). There was no relationship between BMI and the response to MYC ingestion for any of the variables (P < 0.05). Conclusion: The ingestion of mycoprotein within a mixed-meal impacted postprandial glucose kinetics, but not blood glucose or serum insulin concentrations, in individuals of ranging BMI. Clinical Trial Registry Number and Website: This trial was registered at clinicaltrials.gov as NCT04084639 and can be accessed at https://clinicaltrials.gov/ct2/show/NCT04084639 . (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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