Reduced risk for Omicron SARS-CoV-2 infection observed in older adults with hybrid immunity.

Autor:	Pallett SJC; Centre of Defence Pathology, Royal Centre for Defence Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK., Heskin J; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK., Keating F; Royal Hospital Chelsea, Royal Hospital Road, London, UK., Tuck J; Royal Hospital Chelsea, Royal Hospital Road, London, UK.; Mental Health and Veteran's Affairs, Northumbria University, Newcastle-Upon-Tyne, UK., Mazzella A; Institute for Infection and Immunity, St George's University of London, London, UK., Randell P; Institute for Infection and Immunity, St George's University of London, London, UK., Rayment M; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK., Jones R; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK., Mughal N; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK.; North West London Pathology, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK., Davies GW; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK., O'Shea MK; Centre of Defence Pathology, Royal Centre for Defence Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK., Moore LSP; Chelsea Infectious Diseases Research Group, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK.; North West London Pathology, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Du Cane Road, London W12 0NN, UK.
Jazyk:	angličtina
Zdroj:	Age and ageing [Age Ageing] 2024 Jul 02; Vol. 53 (7).
DOI:	10.1093/ageing/afae145
Abstrakt:	Background: Hybrid SARS-CoV-2 immunity may provide longer duration protection against severe SARS-CoV-2 infection and hospitalisation than purely vaccine-derived immunity. Older adults represent a high-risk group for severe disease, yet available data is skewed towards younger adults. Methods: A prospective longitudinal study at a large London long-term care facility (LTCF) was conducted from March 2020 to April 2022 to assess the effect of hybrid versus vaccine-only immunity on SARS-CoV-2 infection in older adults during Omicron variant dominance. Hybrid immunity was assessed by a combination of SARS-CoV-2 polymerase chain reaction testing weekly (asymptomatic screening) and as required (symptomatic testing), as well as serial SARS-CoV-2 serology. Results: 280 participants (median age 82 yrs, IQR 76-88 yrs; 95.4% male) were followed up. 168/280 (60%) had evidence of hybrid immunity prior to the Omicron variant wave. Participants with hybrid immunity had substantially lower odds of acquiring COVID-19 infection during the Omicron wave compared to those with vaccine-only immunity (unadjusted odds ratio 0.26, 95% CI 0.14-0.47, chi-squared P < .0001). Participants with hybrid immunity had an odds ratio of 0.40 (0.19-0.79) for asymptomatic infection and 0.15 (0.06-0.34) for symptomatic infection (Likelihood ratio test, P < .0001). Discussion: Our data highlight potential opportunities to target ongoing booster vaccination campaigns for those most at risk of severe infection. Reporting of data in older adults will be of particular value to examine the effect of hybrid immunity as new variants continue to emerge and vaccination strategies evolve. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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