Marijuana may lead to increased platelet activity in trauma patients.

Autor: Tanner DF; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: DanielleTanner@Creighton.edu., Eastes JG; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: JoelEastes@Creighton.edu., Reeson EA; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: emilyreeson@creighton.edu., Lam EW; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: ericlam@creighton.edu., Rahaman CA; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: clayrahaman@creighton.edu., O'Toole DM; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: devinotoole@creighton.edu., Tolan GC; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: gracetolan@creighton.edu., Babarinde OA; Creighton University School of Medicine Phoenix Regional Campus, St. Joseph's Hospital and Medical Center, Phoenix, AZ USA, USA. Electronic address: oluwatosinbabarinde@creighton.edu., Kupanoff KM; St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: Kristina.Kupanoff@commonspirit.org., Huang DD; St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: Dih-Dih.Huang900@commonspirit.org., Jones MD; St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: Michael.Jones900@commonspirit.org., Czarkowski BR; St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: Brian.Czarkowski@Commonspirit.org., Weinberg JA; St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: Jordan.Weinberg@Commonspirit.org., Bogert JN; St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: James.Bogert@Commonspirit.org.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2024 Dec; Vol. 238, pp. 115822. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1016/j.amjsurg.2024.115822
Abstrakt: Introduction: Delta-9-tetraydrocannabinol (THC) usage is associated with venous thromboembolic events (VTE) in trauma patients. We hypothesized that THC ​+ ​trauma patients would have less platelet inhibition than THC - patients using thromboelastography with platelet mapping (TEG-PM).
Methods: Results from initial TEG- PM assays and patient's UDS were reviewed between 2019 and 2023. Mean levels of arachidonic acid (AA) and adenosine diphosphate (ADP) percent inhibition were compared by THC status.
Results: 793 patients had TEG-PM and UDS data. Mean levels of arachidonic acid (AA) percentage inhibition were 32.6 ​± ​34.2. AA inhibition was lower for THC ​+ ​vs THC- patients (THC+ 23.9 ​± ​27.0 vs THC- 34.3 ​± ​35.3, P ​< ​0.001). There was no association between THC status and ADP inhibition (THC+ 32.5 ​± ​27.1 vs THC- 30.8 ​± ​28.4, P ​= ​0.536).
Discussion: To our knowledge, our data are the first to suggest a clinically measurable increase in platelet reactivity in THC ​+ ​trauma patients. More work is needed to determine if addition of aspirin to the chemoprophylaxis strategy for THC ​+ ​patients would mitigate the known association of THC with VTE.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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