General toxicity and screening of reproductive and developmental toxicity following bioaccumulation of oral-dosed perfluorooctanoic acid: Loss of the Golgi apparatus.

Autor: Jung W; Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, 02447, South Korea., Park H; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, South Korea., Lee BS; Department of Advanced Toxicology Research, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, South Korea., Chang YS; Department of Civil, Urban, Earth and Environmental Engineering, UNIST, 44919, South Korea., Kim JB; Division of Cardiology, Department of Internal Medicine, Kyung-Hee University Hospital, Kyung Hee University, 02447, South Korea., Yang MJ; Jeonbuk Branch Institute, Korea Institute of Toxicology, Jeongup, 56212, South Korea., Lim J; Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, 02447, South Korea., Choi H; National Instrumentation Center for Environmental Management, Seoul National University, South Korea., Park EJ; Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, 02447, South Korea; Human Health and Environmental Toxins Research Center, Kyung Hee University, 02447, South Korea. Electronic address: pejtoxic@khu.ac.kr.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Sep; Vol. 191, pp. 114867. Date of Electronic Publication: 2024 Jul 11.
DOI: 10.1016/j.fct.2024.114867
Abstrakt: Despite its widespread use as a stabilizer across various industries over the past several decades, the health effects of chronic exposure to PFOA are still unclear. We administered PFOA by oral gavage (0, 12.5, 50, and 200 μg/day/mouse, eight groups) to male and female mice for six months. Body weight gain decreased with dose accompanied by increased liver weight, and PFOA altered liver damage-related-blood biochemical indicators and induced pathological lesions, including hepatocellular hypertrophy, cholangiofibrosis, and centrilobular hepatocellular vacuolation. Loss of the Golgi apparatus, formation of lamellar body-like structures, and lipid accumulation were observed in the liver of PFOA-treated mice. We also cohabited five pairs of male and female mice for the last ten days of administration, dosed PFOA to dam up to 28 days after birth, and investigated effects on reproduction and development. The survival rate of pups and the sex ratio of surviving mice decreased significantly at the highest dose. PFOA tissue concentration increased with the dose in the parent mice's liver and the pups' blood and brain. Taken together, we suggest that PFOA primarily affects the liver and reproduction system and that disturbance in lipid metabolism and Golgi's structural stability may be involved in PFOA-induced toxicity.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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