Modelling intracellular transport in crowded environments: effects of motor association to cargos.

Autor: Mukherji S; Mathematical and Physical Sciences Division, School of Arts and Sciences, Ahmedabad University, Navrangpura, Ahmedabad, 380009, India. sutapa.mukherji@ahduni.edu.in., Patel DK; Mathematical and Physical Sciences Division, School of Arts and Sciences, Ahmedabad University, Navrangpura, Ahmedabad, 380009, India.
Jazyk: angličtina
Zdroj: The European physical journal. E, Soft matter [Eur Phys J E Soft Matter] 2024 Jul 13; Vol. 47 (7), pp. 47. Date of Electronic Publication: 2024 Jul 13.
DOI: 10.1140/epje/s10189-024-00440-9
Abstrakt: In intracellular transports, motor proteins transport macromolecules as cargos to desired locations by moving on biopolymers such as microtubules. Recent experiments suggest that, while moving in crowded environments, cargos that can associate motor proteins during their translocation have larger run-length and association time compared to free motors. Here, we model the dynamics of a cargo that can associate at the most m free motors present on the microtubule track as obstacles to its motion. The proposed models display competing effects of association and crowding, leading to a peak in the run-length with the free-motor density. For m = 2 and 3, we show that this feature is governed by the largest eigenvalue of the transition matrix describing the cargo dynamics. In all the above cases, free motors are assumed to be present on the microtubule as stalled obstacles. We finally compare simulation results for the run-length for general scenarios where the free motors undergo processive motion in addition to binding and unbinding to or from the microtubule.
(© 2024. The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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