Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress.

Autor: Kolodeeva OE; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. oekolodeeva@hse.ru., Kolodeeva OE; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. okolodeeva@hse.ru., Averinskaya DA; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. daverinskaya@hse.ru., Makarova YA; Faculty of Biology and Biotechnology, HSE University, Moscow, Russia. jmakarova@hse.ru.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. jmakarova@hse.ru.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2024 Aug; Vol. 517 (1), pp. 264-268. Date of Electronic Publication: 2024 Jul 13.
DOI: 10.1134/S1607672924600301
Abstrakt: Translation inhibition can activate two cell death pathways. The first pathway is activated by translational aberrations, the second by endoplasmic reticulum (ER) stress. In this work, the effect of ribosome-inactivating protein type II (RIP-II) viscumin on M1 macrophages derived from the THP-1 cell line was investigated. The number of modified ribosomes was evaluated by real-time PCR. Transcriptome analysis revealed that viscumin induces the ER stress activated by the PERK sensor.
(© 2024. The Author(s).)
Databáze: MEDLINE
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