| Autor: |
Liu FH; Institute of Translational Medicine, Nanchang University, Nanchang 330001, China., Lin XC; Institute of Translational Medicine, Nanchang University, Nanchang 330001, China., Liu YW; Institute of Translational Medicine, Nanchang University, Nanchang 330001, China., Zhang TT; Institute of Translational Medicine, Nanchang University, Nanchang 330001, China., Zhang YB; Department of Neurology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China., Xie ZL; Joint Program of Nanchang University and Queen Mary University of London, Nanchang 330001, China., Zhan Y; Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China., Hu P; Institute of Translational Medicine, Nanchang University, Nanchang 330001, China. |
| Abstrakt: |
Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells. |
