The intensity of subacute local biological effects after the implantation of ALBO-OS dental material based on hydroxyapatite and poly(lactide-co-glycolide): in vivo evaluation in rats.
| Autor: | Ilić V; Department of General and Oral Histology and Embryology, School of Dental Medicine, University of Belgrade, Beograd, Serbia., Biočanin V; Faculty of Dentistry in Pančevo, University of Business Academy, Novi Sad, Serbia., Antonijević Đ; Department of Anatomy, School of Dental Medicine, University of Belgrade, Beograd, Serbia., Petrović B; Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, Belgrade University, Belgrade, Serbia., Jokanović V; ALBOS d.o.o. Belgrade, Serbia., Ilić D; Department for Restorative Dentistry and Endodontics, School of Dental Medicine, University of Belgrade, Beograd, Serbia., Danilović V; Department of General and Oral Histology and Embryology, School of Dental Medicine, University of Belgrade, Beograd, Serbia., Japundžić-Žigon N; Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Beograd, Serbia., Paraš S; Faculty of Natural Sciences and Mathematics, University of Banja Luka, Banja Luka, Bosnia and Herzegovina., Milutinović J; Faculty of Dentistry in Pančevo, University of Business Academy, Novi Sad, Serbia., Milutinović-Smiljanić S; Department of General and Oral Histology and Embryology, School of Dental Medicine, University of Belgrade, Beograd, Serbia. |
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| Jazyk: | angličtina |
| Zdroj: | Biomedizinische Technik. Biomedical engineering [Biomed Tech (Berl)] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15. |
| DOI: | 10.1515/bmt-2023-0640 |
| Abstrakt: | Objectives: This study aimed to evaluate the intensity of the subacute local biological effects after implantation and osseoconductive potential of novel hydroxyapatite-based bone substitute coated with poly (lactide-co-glycolide), named ALBO-OS, in comparison to Bio-Oss ® . Methods: Fifteen male Wistar rats, randomly assigned into groups: 10, 20, and 30 days (n꞊5), were subcutaneously implanted with ALBO-OS and Bio-Oss ® . Furthermore, artificially made bone defects on both rat's tibias were implanted with experimental materials. Unimplanted defects represented negative control. After the animals' euthanizing, tissue samples were prepared and analyzed histologically and histomorphometrically. Results: Normal healing of the epithelial tissue was observed, with no signs of infection or necrosis. Minimal vascular congestion was noted immediately around the graft, with no signs of tissue oedema, with a minimal capsule thickness. The applied material did not cause an inflammatory response (IR) of significant intensity, and 20 days after implantation, the IR was mainly assessed as minimal. The tibial specimen showed that ALBO-OS has good osseoconductive potential, similar to Bio-Oss ® , as well as low levels of acute and subacute inflammation. Conclusions: The tested material exhibits satisfying biocompatibility, similar to Bio-Oss ® . (© 2024 Walter de Gruyter GmbH, Berlin/Boston.) |
| Databáze: | MEDLINE |
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