The Impact of Expert Pathology Review and Molecular Diagnostics on the Management of Sarcoma Patients: A Prospective Study of the Hellenic Group of Sarcomas and Rare Cancers.

Autor:	Kokkali S; Oncology Unit, 2nd Department of Medicine, Medical School, Hippocratio General Hospital of Athens, National and Kapodistrian University of Athens, V. Sofias 114, 11527 Athens, Greece., Boukovinas I; Oncology Department, Bioclinic of Thessaloniki, 54622 Thessaloniki, Greece., de Bree E; Department of Surgical Oncology, University Hospital of Heraklion, 71110 Heraklion, Greece., Koumarianou A; Hematology Oncology Unit, Fourth Department of Internal Medicine, School of Medicine, National Kapodistrian University of Athens, 12462 Athens, Greece., Georgoulias V; Hellenic Oncology Research Group (HORG), 11526 Athens, Greece., Kyriazoglou A; Medical Oncology Unit, Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece., Tsoukalas N; Department of Oncology, 401 General Military Hospital of Athens, 11525 Athens, Greece., Memos N; 2nd Department of Surgery, School of Medicine, Aretaieion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece., Papanastassiou J; Department of Orthopedic Oncology, 'Agioi Anargyroi' General Hospital, 14564 N.Kifisia, Greece., Stergioula A; Department of Radiation Oncology, 'Iaso' Hospital, 15123 Marousi, Greece.; Department of Tomotherapy-Stereotactic Radiosurgery 'Iatropolis', 15231 Chalandri, Greece., Tsapakidis K; Department of Medical Oncology, University Hospital of Larissa, 41334 Larissa, Greece., Loga K; Department of Medical Oncology, School of Medicine, Faculty of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece., Duran-Moreno J; Hellenic Group of Sarcoma and Rare Cancers, G. Theologou 5, 11471 Athens, Greece., Papanastasopoulos P; Oncology Unit, ST Andrews General Hospital of Patras, 26332 Patras, Greece., Vassos N; Division of Surgical Oncology and Thoracic Surgery, Mannheim University Medical Center, University of Heidelberg, 68167 Mannheim, Germany.; Department of Surgical Oncology, Athens Medical Center, 15125 Athens, Greece., Kontogeorgakos V; 1st Department of Orthopaedic Surgery, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece., Athanasiadis I; Oncology Department, Hygeia Athens Private Hospital, 15123 Maroussi, Greece., Mahaira L; Department of Genetics, Saint Savvas Cancer Hospital, 11522 Athens, Greece., Dimitriadis E; Department of Genetics, Saint Savvas Cancer Hospital, 11522 Athens, Greece., Papachristou DJ; Unit of Bone and Soft Tissue Studies, Department of Histology and Histopathology, School of Medicine, University of Patras, 26504 Patras, Greece., Agrogiannis G; Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Jazyk:	angličtina
Zdroj:	Cancers [Cancers (Basel)] 2024 Jun 24; Vol. 16 (13). Date of Electronic Publication: 2024 Jun 24.
DOI:	10.3390/cancers16132314
Abstrakt:	Precise classification of sarcomas is crucial to optimal clinical management. In this prospective, multicenter, observational study within the Hellenic Group of Sarcoma and Rare Cancers (HGSRC), we assessed the effect of expert pathology review, coupled with the application of molecular diagnostics, on the diagnosis and management of sarcoma patients. Newly diagnosed sarcoma patients were addressed by their physicians to one of the two sarcoma pathologists of HGSRC for histopathological diagnostic assessment. RNA next-generation sequencing was performed on all samples using a platform targeting 86 sarcoma gene fusions. Additional molecular methods were performed in the opinion of the expert pathologist. Therefore, the expert pathologist provided a final diagnosis based on the histopathological findings and, when necessary, molecular tests. In total, 128 specimens from 122 patients were assessed. Among the 119 cases in which there was a preliminary diagnosis by a non-sarcoma pathologist, there were 37 modifications in diagnosis (31.1%) by the sarcoma pathologist, resulting in 17 (14.2%) modifications in management. Among the 110 cases in which molecular tests were performed, there were 29 modifications in diagnosis (26.4%) through the genomic results, resulting in 12 (10.9%) modifications in management. Our study confirms that expert pathology review is of utmost importance for optimal sarcoma diagnosis and management and should be assisted by molecular methods in selected cases.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF