| Autor: |
Goufman EI; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Tikhonova NB; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Aleksankin AP; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Gershkovich KB; N. M. Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia., Stepanov AA; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Stepanova II; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Mikhaleva LM; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Nizyaeva NV; Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', 117418 Moscow, Russia., Kovaleva OV; Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology», 115478 Moscow, Russia., Alferov AA; Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology», 115478 Moscow, Russia., Kuzmin YB; Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology», 115478 Moscow, Russia., Kushlinskii NE; Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology», 115478 Moscow, Russia. |
| Abstrakt: |
Blood serum of patients with gastric ( n = 68) and esophageal ( n = 43) cancer was assessed for proteolytic fragments of IgG. Serum samples of 20 healthy donors were used as a control. We analyzed indicators of hemostasis (prothrombin time, fibrinogen, plasminogen activity, a2-antiplasmin activity, protein C activity) in blood plasma and the level of total IgG in the blood serum. The median IgG-LysK of healthy donors was lower than in esophageal cancer and in patients with gastric cancer. ROC-analysis showed high sensitivity (91%) and specificity (85%) in the group with esophageal cancer but 68% and 85%, respectively, in patients with gastric cancer. Analysis of false negatives IgG-LysK in cancer patients showed that most patients had an advanced stage of cancer accompanied by metastases. Total IgG in the plasma of patients with false-negative IgG-LysK values was 30% lower than in samples with positive values, while the level of a2-antiplasmin was increased and the prothrombin time was shorter. These changes in blood homeostasis may be the reason for an increase in the proportion of false-negative values of the IgG-LysK coefficient. Circulatory IgG-LysK levels increase in the early stages of such cancers as gastric and esophageal cancers. Thus, when used in a panel with other more specific markers for these pathologies, this indicator can significantly increase the early detection of cancer. |
